Tamsulosin Hydrochloride
Indications
Taspia is used to relieve the functional symptoms of benign prostatic hyperplasia (BPH), an enlarged prostate.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Tamsulosin is a selective alpha1 adrenoceptor blocking agent, and it acts preferentially on alpha1A adrenoceptors found in the human prostate. Blocking these receptors relaxes smooth muscle in the bladder neck and prostate, which improves urine flow and eases BPH symptoms. When Tamsulosin hydrochloride 0.4mg capsules are taken by mouth under fasting conditions, absorption is essentially complete, at about 90%. Under fasting conditions, the maximum plasma concentration (Tmax) is reached in four to five hours, while taking it with food delays this to six to seven hours. Tamsulosin hydrochloride binds very extensively to human plasma protein, in the range of 94% to 99%. It undergoes extensive metabolism by cytochrome P450 enzymes in the liver, with less than 10% of the dose excreted in urine unchanged. After intravenous or oral dosing of an immediate release formulation, its plasma elimination half life ranges from five to seven hours. However, because Prostam capsules control the rate of absorption, the apparent half life of Tamsulosin hydrochloride is longer: about 9 to 13 hours in healthy volunteers and 14 to 15 hours in the target patient population.
Pregnancy & Breastfeeding
Use of Tamsulosin during pregnancy and breastfeeding is not recommended.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.