Solifenacin Succinate
Indications
Solif is used to relieve the symptoms of overactive bladder syndrome. These symptoms may include urge incontinence (a sudden, strong need to pass urine that leads to leakage), passing urine more often than usual, and a sense of urgency to urinate.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Solifenacin works by blocking muscarinic receptors, acting as a competitive antagonist with its strongest affinity for the M3, M1, and M2 subtypes. In the bladder, most muscarinic receptors (about 80%) are the M2 type, with the remaining 20% being M3. By blocking M3 receptors, solifenacin stops the detrusor muscle from contracting, while its action on M2 receptors may further help relax smooth muscle in the bladder wall.
Pregnancy & Breastfeeding
Pregnancy: There is no clinical data on women who became pregnant while using Solifenacin. Animal studies have not shown direct harm to fertility, foetal development, or delivery, but the risk to humans is not known. Solifenacin should be prescribed to pregnant women only with caution.
Breastfeeding: It is not known whether Solifenacin passes into human breast milk. In mice, however, Solifenacin and/or its breakdown products were found in milk and led to poor growth in nursing pups in a dose-dependent manner. For this reason, Solifenacin should not be used while breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.