Informational only — Not medical advice. Always consult a licensed healthcare provider.

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Community data Updated 2 months ago
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Indications

Migraine Epilepsy Bipolar Disorder

Valepi is used to treat all types of epilepsy, including partial seizures, absence seizures (petit mal), generalized tonic-clonic seizures (grand mal), myoclonic seizures, atonic seizures, and mixed seizures involving absence attacks. It is also used for the prophylaxis of febrile convulsions and the prophylaxis of post-traumatic epilepsy. Valepi is also indicated for the treatment of bipolar disorder and the prophylaxis of migraine.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Sodium Valproate, the active ingredient of this preparation is endowed with anti-epileptic activity against a variety of seizures. The mechanism by which Sodium Valproate exerts its anti-epileptic effects has not been established. However, it has been suggested that its activity is related to increase brain levels of gamma-aminobutyric acid (GABA).

Pregnancy & Breastfeeding

Sodium Vaiproate crosses the placenta and in humans, exposure to valproate in the first trimester has been associated with neural tube defects such as anencephaly and spina bifida in newborn. Pregnant women treated with Sodium Vaiproate should be offered to estimate serum a-fetoprotein. Sodium Valproate is excreted in breast miik. However, breast-feeding by a mother taking Sodium Valproate probably causes no risk to the child.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Oral: Sodium Valproate tablets may be taken once or twice a day, while the syrup should be given in divided doses. Epilepsy: Adults should initially receive 600 mg daily in 2 divided doses, preferably after food, increasing by 200 mg/day at 3-day intervals up to a maximum of 2.5 g daily in divided doses until seizures are controlled. The usual maintenance dose is 1-2 g daily (20-30 mg/kg daily). For children over 20 kg, the initial dose is 400 mg daily in divided doses, increased until control is achieved (usually within the range of 20-30 mg/kg daily), up to a maximum of 35 mg/kg daily. For children up to 20 kg, the initial dose is 20 mg/kg daily in divided doses. Febrile convulsion: 20-30 mg/kg/day in 3 divided doses. Bipolar disorder: Initially 600 mg daily (20-30 mg/kg/day) in 2-3 divided doses. The maintenance dosage is 1000-2000 mg daily. Prophylaxis of migraine: 400-600 mg daily, although some patients may require 1000-1500 mg daily. Injection: In adults, a slow intravenous injection may be given over 3-5 minutes, usually 400-800 mg depending on body weight (up to 10 mg/kg), followed by continuous or repeated infusion up to a maximum of 2500 mg/day. In children, the initial dose is 20-30 mg/kg/day, up to a maximum of 40 mg/kg/day. It may be given by direct slow intravenous injection or by infusion using compatible diluents such as 0.9% Sodium Chloride injection or 5% Dextrose injection.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.