Indications
Relsin capsule is used to treat the signs and symptoms of benign prostatic hyperplasia (BPH). It is highly effective for BPH and has the highest uroselectivity for the alpha-1 adrenergic receptor. It is an effective treatment option for BPH in patients who have not responded to tamsulosin. It does not cause orthostatic hypotension and offers convenient once-daily dosing. Relsin is not indicated for the treatment of hypertension.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Silodosin selectively blocks post-synaptic alpha-1 adrenoreceptors found in the human prostate, bladder base, bladder neck, prostatic capsule, and prostatic urethra. By blocking these receptors, it relaxes smooth muscle in these tissues, which improves urine flow and reduces BPH symptoms.
Pregnancy & Breastfeeding
Pregnancy Category B. Silodosin is not indicated for use in women. In an embryo/fetal study, pregnant rabbits given 200 mg/kg/day (about 13 to 25 times the maximum recommended human exposure, or MRHE, of Silodosin by AUC) showed decreased maternal body weight; no statistically significant teratogenicity was seen at this dose. In pregnant rats, Silodosin given during organogenesis at 1000 mg/kg/day (about 20 times the MRHE) was not teratogenic, and no effects on the mother or fetus were observed at this dose. Rats and rabbits do not produce glucuronidated Silodosin, a compound found in human serum at roughly 4 times the level of circulating Silodosin and with pharmacological activity similar to Silodosin's. When rats were treated throughout pregnancy and lactation at doses up to 300 mg/kg/day, no effects on the offspring's physical or behavioral development were seen.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.