Informational only — Not medical advice. Always consult a licensed healthcare provider.

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Community data Updated 2 months ago
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Indications

Sevoflurane is used to induce and maintain general anesthesia in adults and children undergoing surgery, whether they are staying in hospital or going home the same day. Each ml of the inhalation liquid contains 100% v/v Sevoflurane USP.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Sevoflurane is a volatile liquid preparation given by inhalation. It is used as an anesthetic agent for both inducing and maintaining general anesthesia. The minimum alveolar concentration (MAC) of Sevoflurane decreases with age. Because it is only weakly soluble in blood and tissue, a sufficient alveolar concentration to produce anesthesia is reached quickly, and it is eliminated from the body just as quickly once anesthesia is stopped. Sevoflurane brings about loss of consciousness, a reversible loss of pain sensation and motor activity, a reduction in autonomic reflexes, and depression of respiratory and cardiovascular function; these effects depend on the dose given. With a low blood/gas partition coefficient of 0.65, Sevoflurane also allows patients to recover from anesthesia quickly.

Pregnancy & Breastfeeding

Pregnancy: Well-controlled safety studies of sevoflurane in pregnant women are lacking, and its safety during labor and delivery has not been established. The drug can relax the uterine smooth muscle, which may contribute to uterine atony.

Lactation: It is not known whether sevoflurane or its breakdown products pass into breast milk. To limit the infant's exposure, a breastfeeding mother may choose to pump and discard her milk for the first 24 hours after receiving sevoflurane. Sevoflurane should be used with caution in nursing mothers.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Route of administration: Sevoflurane should be given by inhalation, delivered from a vaporizer. The concentration being delivered should be known, which can be achieved using a vaporizer calibrated specifically for Sevoflurane. It should be administered only by persons trained in giving general anesthesia, and facilities for maintaining a patent airway, artificial ventilation, oxygen enrichment and circulatory resuscitation must be immediately available. Since the level of anesthesia can change rapidly, only vaporizers that produce predictable concentrations of Sevoflurane should be used. General anesthesia must always be given according to the individual patient's response. Pre-anesthetic medication: No specific premedication is either indicated or contraindicated with Sevoflurane. Whether to premedicate, and the choice of premedication, is left to the anesthesiologist's discretion. Induction: Sevoflurane has a nonpungent odor and does not cause respiratory irritability, making it suitable for mask induction in both children and adults. Maintenance: Surgical levels of anesthesia can usually be reached with concentrations of 0.5 to 3% Sevoflurane, with or without the concomitant use of nitrous oxide. Sevoflurane can be given with any type of anesthesia circuit. Use in children and adolescents: The safety and efficacy of induction and maintenance of general anesthesia with Sevoflurane have been established in pediatric patients aged 1 to 18 years.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.