Informational only — Not medical advice. Always consult a licensed healthcare provider.

MedBD
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Community data Updated 2 months ago
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Indications

Tuberculosis

In treating both tuberculosis and the meningococcal carrier state, the small number of resistant cells present within a large population of susceptible cells can quickly become the dominant type. Bacteriologic cultures should be taken before starting therapy to confirm that the organism is susceptible to rifampicin, and these cultures should be repeated throughout treatment to monitor the response. Because resistance can develop quickly, susceptibility testing should be carried out if cultures remain positive during the course of treatment. If test results show resistance to rifampicin and the patient is not responding to therapy, the treatment regimen should be modified.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Rifampicin binds to the β subunit of DNA-dependent RNA polymerase in susceptible bacteria, blocking chain initiation for RNA synthesis and thereby inhibiting transcription.

Pregnancy & Breastfeeding

Pregnancy: If rifampicin is given during the final weeks of pregnancy, it can cause post-natal hemorrhage in both the mother and the newborn, and treatment with vitamin K may be needed as a result.

Nursing Mothers: Animal studies have shown a potential for tumorigenicity with rifampicin, so nursing mothers and their doctors should weigh how important the drug is to the mother against this risk when deciding whether to stop breastfeeding or stop the medicine.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Rifampin can be administered by the oral route or by IV infusion. IV doses are the same as those for oral.Tuberculosis: Adults: 10 mg/kg, in a single daily administration, not to exceed 600 mg/day, oral or IV Pediatric Patients: 10–20 mg/kg, not to exceed 600 mg/day, oral or IV It is recommended that oral rifampin be administered once daily, either 1 hour before or 2 hours after a meal with a full glass of water.Rifampin is indicated in the treatment of all forms of tuberculosis. A three-drug regimen consisting of rifampin, isoniazid, and pyrazinamide is recommended in the initial phase of shortcourse therapy which is usually continued for 2 months. The Advisory Council for the Elimination of Tuberculosis, the American Thoracic Society, and the Centers for Disease Control and Prevention recommend that either streptomycin or ethambutol be added as a fourth drug in a regimen containing isoniazid (INH), rifampin and pyrazinamide for initial treatment of tuberculosis unless the likelihood of INH resistance is very low. The need for a fourth drug should be reassessed when the results of susceptibility testing are known. If community rates of INH resistance are currently less than 4%, an initial treatment regimen with less than four drugs may be considered.Following the initial phase, treatment should be continued with rifampin and isoniazid for at least 4 months. Treatment should be continued for longer if the patient is still sputum or culture positive, if resistant organisms are present, or if the patient is HIV positive.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.