Informational only — Not medical advice. Always consult a licensed healthcare provider.

MedBD
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Community data Updated 2 months ago
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Indications

Celbarin, when combined with Peginterferon alfa-2a or Interferon alfa, is used to treat chronic hepatitis C (CHC) infection in patients aged 5 years and older who have compensated liver disease and have not previously received interferon alpha treatment. Celbarin is not effective when used alone and should never be taken as a standalone therapy.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Ribavirin is a man-made (synthetic) nucleoside that works against several viruses, including respiratory syncytial virus, influenza virus and herpes simplex virus. Exactly how it works is not fully understood. It is thought to act at more than one site in the cell, including certain cellular enzymes, to interfere with the virus's ability to build its nucleic acid. Its mono- and triphosphate forms are the derivatives known to be responsible for this antiviral effect.

Pregnancy & Breastfeeding

Pregnancy: Ribavirin must not be used by pregnant women or who are expecting child since the drug may have teratogenic effect. Male patients and their female partners of childbearing age must be counselled to use 2 forms of effective contraception during treatment with ribavirin and for 6 months after treatment has been concluded. Ribavirin should not be initiated until a report of a negative pregnancy test has been obtained immediately prior to initiation of therapy. Patients must perform a pregnancy test monthly during therapy and for 6 months post therapy.Brestfeeding: It is not known whether ribavirin is excreted in human milk. Because of the potential for adverse reactions in nursing infants, a decision should be made either to discontinue nursing or not to initiate therapy.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: The recommended treatment duration for patients who have not previously been treated with Interferon or Peginterferon is 24 to 48 weeks. Ribavirin is taken by mouth at a daily dose of 800 mg to 1200 mg, split into two doses given in the morning and evening. For genotypes 2 and 3, treatment beyond 24 weeks has not shown any added benefit. Special dosing notes: If severe adverse reactions or abnormal lab results occur during treatment, the dose should be adjusted until these effects settle. Because ribavirin therapy is known to cause haemolysis, separate guidelines apply to patients with a history of cardiovascular disease. Use in kidney impairment: Patients with a creatinine clearance of 50 ml/minute or less should receive a reduced total daily dose of Ribavirin. Use in the elderly (65 years and older): There is not enough clinical study data on the effectiveness and safety of Ribavirin combined with interferon alfa or pegylated interferon alfa in this age group. Use in children under 5 years: The safety and effectiveness of Ribavirin combined with interferon alfa or pegylated interferon alfa have not been evaluated in this age group.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.