Rabies Vaccine

Indications

Verorab is used to provide protective immunization against rabies and to treat patients following suspected exposure to rabies. As a pre-exposure immunization, it is given to professional groups who face frequent risk of contamination, including veterinary surgeons (including students at veterinary colleges), technical personnel working with veterinary surgeons, laboratory personnel handling material contaminated with rabies virus, personnel in abattoirs and knackers' yards, taxidermists, gamekeepers, forestry workers and naturalists in enzootic areas, and infants who are particularly exposed to the risk of rabies. As a post-exposure treatment, it is given to those bitten by rabid animals or by animals suspected of being rabid, as well as to treat contact subjects.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Rabies Vaccine for human use comes as a freeze-dried preparation made from inactivated rabies virus grown on Vero cells. Once reconstituted, it forms a clear, colorless, sterile solution intended for intramuscular injection.

Pregnancy & Breastfeeding

Pregnancy: The potential risk of receiving rabies vaccine during pregnancy is not known. Because rabies itself is so severe, pregnancy is not regarded as a reason to withhold post-exposure prophylaxis.

Lactation: It is not known whether the vaccine passes into human breast milk. Because rabies itself is so severe, breast-feeding is not regarded as a contraindication.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Dosage To reconstitute the vaccine, transfer content of supplied diluent into the vial containing freeze-dried preparation. Do not shake. After reconstitution the solution should be homogeneous, clear and free from any particles. Vaccine must be injected immediately after reconstitution and the syringe should be destroyed after use.Method of administration for intramuscular use: The 1 ml dose of Rabies vaccine should be given intramuscularly in the deltoid in adults and in the anterolateral aspect of the thigh muscle in children under 1 year. It should not be injected into the gluteal region. Do not inject intravenously.Pre-exposure immunization: 1 ml for children and adults. Primary-vaccination: According to the WHO recommendations 1 injection by the intramuscular route on days DO, D7, D21 or D28, followed by a booster dose one year later. Boosters: Thereafter, one injection every 5 years or when the titre is found to be less than 0.5 lU/ml Post-exposure immunization: Local treatment of the wound: Prompt and gentle through washing with soap or detergent and flushing the wound with running tap water for at least 15 minutes. After washing, disinfectants like either ethanol (700 ml/l) or tincture or aqueous solution of iodine or povidone iodine must be applied. Don't bandage or suture the wound. Vaccination of non-immunized subjects Intramuscular schedules: One Intramuscular (IM) dose comprised of 1 ml. Standard intramuscular (1-1-1-1-1) regimen: Day 0: 1 injection of 1 ml Day 3: 1 injection of 1 ml Day 7: 1 injection of 1 ml Day 14: 1 injection of 1 ml Day 28: 1 injection of 1 ml Or abbreviated multisite (2-1-1) regimen: Day 0: 2 injections each of 1 ml at separate sites Day 7: 1 injection of 1 ml Day 21: 1 injection of 1 ml In case of severe (WHO category 3) wounds, rabies immunoglobulin should be administered as soon as possible with the first dose of rabies vaccine. The anti-rabies immunoglobulin should be used as local wound soakage injections as much as possible, with the rest part for muscle injection. The rabies vaccine should be administered in different injection site.Vaccination of subjects already immunized: Patients had complete post exposure immunization schedule within 1 year. Bitten by suspected rabid animal, 1 dose injection is required on Day 0, Day 3, respectively. Patients had complete post-exposure immunization schedule 1 year ago, Bitten by suspected rabid animal, complete post-exposure immunization required. Patient had complete immunization schedule and booster immunization within 3 years. Bitten by suspected rabid animal, 1 dose injection is required on Day 0, Day 3, respectively. Patient had complete immunization schedule and booster immunization 3 years ago. Bitten by suspected rabid animal, complete post-exposure immunization required. Post-exposure vaccination must be administered on the basis of severity under medical supervision.