Informational only — Not medical advice. Always consult a licensed healthcare provider.

Community data Updated 2 months ago

Indications

Propranolol is used to treat essential hypertension, angina pectoris, and cardiac arrhythmia, as well as thyrotoxicosis and anxiety. It is also used for the prophylaxis of migraine, among other indications.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Propranolol Hydrochloride belongs to a group of medicines called beta-adrenergic receptor blockers, and it is commonly used to treat high blood pressure and angina pectoris (chest pain caused by reduced blood flow to the heart). It works by blocking the action of catecholamines at beta-adrenergic receptors, which keeps the heart from beating too fast or too forcefully and reduces the heart's oxygen demand.

When taken by mouth, propranolol is nearly completely absorbed from the gut, though part of the dose is broken down by the liver before it reaches general circulation, as it passes through the portal blood supply. Blood levels peak within 1 to 1.5 hours of an oral dose, and the drug stays in the body with a half-life of roughly 3 to 6 hours. Its breakdown products are then cleared from the body in the urine.

Pregnancy & Breastfeeding

Propranolol falls under pregnancy category C and should not be used in pregnant women. It passes into human breast milk, so caution is advised when giving it to a nursing mother.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Adult (above 18 years): Hypertension: Initially 80 mg twice daily, may be increased at weekly intervals and then maintenance dose of 160 to 320 mg daily is recommended. Angina pectoris: Initially 40 mg 2 to 3 times daily and then maintenance dose of 120 to 240 mg daily is given. Thyrotoxicosis: 10 to 40 mg, 3 to 4 times daily is given. Anxiety: 40 mg once daily, may be increased to three times daily. Prophylaxis of migraine: Initially 40 mg 2 to 3 times daily; then maintenance dose of 80 to 160 mg daily is recommended. Child (From day 1 to 18 years): Hypertension: Neonate: 0.25 to 0.5 mg/kg 3 times daily, adjusted according to response. Child from 1 month to 12 years: 0.25 to 1 mg/kg 3 times daily, maximum dose 5 mg/kg daily in divided dose. Child 12 to 18 years: initially 80 mg twice daily, maintain 160 to 320 mg daily.

Side Effects & Interactions