Propantheline Bromide
Indications
Propa is used in the treatment of the following conditions. It serves as adjunctive therapy in the treatment of peptic ulcer (gastric and duodenal). It provides relief of the symptoms of gastritis (stomach upset, gastrointestinal bleeding, blood in vomit, blood in stool, persistent pain). It is used for the symptomatic treatment of diarrhoea related irritable bowel syndrome (irritable colon, spastic colon, acute enterocolitis, functional GI disorders etc). It is also used for urinary incontinence and for the control of salivation and enuresis. It improves lactose intolerance and prevents excessive sweating (hyperhidrosis).
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Propantheline Bromide acts by dual mechanism of action. Specific anticholinergic effect (antimuscarinic) at the acetylcholine-receptor sites Direct effect upon smooth muscle (musculotropic). This medication is a muscarinic antagonist having antispasmodic properties. It reduces the effect of acetylcholine, a chemical released from nerves that stimulates muscles, by blocking the receptors for acetylcholine on smooth muscle. It also has a direct relaxing effect on smooth muscle. In addition, Propantheline inhibits gastrointestinal motility and decreases gastric acid secretion and controls excessive pharyngeal, tracheal and bronchial secretions. Other secretions like pancreatic juice, sweat and saliva are also reduced.
Pregnancy & Breastfeeding
Propantheline bromide falls under pregnancy category C. No animal reproduction studies have been carried out with this drug, so it should only be used during pregnancy if the need is clearly established. Whether it passes into breast milk is also unknown; since many medicines do pass into breast milk, it should be used with caution in breastfeeding mothers. As with other anticholinergic medicines, it may also reduce milk supply.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.