Informational only — Not medical advice. Always consult a licensed healthcare provider.

Community data Updated 2 months ago

Indications

Kdrin is used as an adjunctive treatment for all forms of parkinsonian syndrome. It is mainly used for the symptomatic treatment of idiopathic (paralysis agitans), postencephalitic and arteriosclerotic parkinsonism. It is also used to control troublesome extrapyramidal symptoms, including pseudoparkinsonism, acute dystonic reactions, and akathisia induced by neuroleptic drugs such as phenothiazine derivatives.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Procyclidine hydrochloride is an antimuscarinic medicine used to treat Parkinson's disease, and it carries relatively low toxicity. It is a synthetic tertiary amine. The drug works by correcting the relative excess of cholinergic activity that is thought to occur in Parkinson's disease as a result of reduced dopamine levels. It is absorbed from the gastrointestinal tract and clears from body tissues fairly quickly. When given intravenously, it starts working within 5 to 20 minutes, and its effects last for up to 4 hours.

Pregnancy & Breastfeeding

Because procyclidine may be used during pregnancy or while breastfeeding, and in women who could become pregnant, the doctor and patient should weigh the potential benefits against the possible risks to both mother and child before it is used.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Tablet: Give by mouth, preferably after meals. For parkinsonism, start with 2.5 mg three times a day, then increase to 5 mg three times a day, with an occasional 5 mg dose at bedtime. Adjust the dose as tolerated until the total daily amount reaches 20 to 30 mg, split into 3 to 4 doses. For drug induced extrapyramidal symptoms, start with 2.5 mg three times a day, then raise the dose by 2.5 mg increments per day as needed and tolerated. Injection: 5 to 10 mg, which may be repeated after 20 minutes if necessary, up to a maximum of 20 mg a day.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.