Informational only — Not medical advice. Always consult a licensed healthcare provider.

MedBD
বাং
Community data Updated 2 months ago

Pheniramine Maleate

Sedating Anti-histamine Prescription
Check interactions
🌐 বাংলায় দেখুন

Indications

Allergic Rhinitis Fever Vertigo Nausea and Vomiting Diabetes Mellitus Eczema Urticaria Allergy Conjunctivitis Edema

Alervil is used for allergic conditions such as hay fever, drug rashes, angioneurotic edema, serum sickness, allergic conjunctivitis and food allergy. It is also used for conditions of the respiratory tract that involve increased secretion, including vasomotor rhinitis and acute rhinitis. It is used for all itching skin conditions, including neurodermatitis, eczema of any origin, lichen planus, acute and chronic urticaria, itching of the anus or genitals, itching due to jaundice and diabetes, and radiation sickness. It is also used to prevent and treat motion sickness, and to prevent and treat nausea, vomiting and vertigo caused by Meniere's disease and other disturbances of the inner ear.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Pheniramine competes with histamine for the H1 receptor and behaves as an inverse agonist once it binds. This drop in H1 receptor activity is what reduces itching, and it also lessens vasodilation and capillary leakage, which in turn means less redness and swelling. This effect shows up clearly as suppression of the histamine-induced wheal (swelling) and flare (vasodilation) response. Inverse agonism at H1 receptors in the CNS is also what causes the drowsiness typical of first-generation antihistamines such as pheniramine. Pheniramine can also bind to H4 receptors and act as an inverse agonist there too, which may further ease itching by curbing inflammation.

Pregnancy & Breastfeeding

Pregnancy Category A. Should be used only when clearly indicated.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Doses must always be worked out for each individual patient and should be taken with food or shortly afterwards. Treatment should begin at the lowest possible dose, since experience has shown that antihistamines are often effective at low doses. The maximum dose of 3 mg/kg per day must not be exceeded. Elderly patients should use the adult dose with caution. To prevent travel sickness, it is recommended that the first dose be taken at least 30 minutes before setting off. Because of the risk of drowsiness, patients should not drive a motor vehicle or operate machinery after taking a dose. For Pheniramine Maleate tablets, adults and children over 10 years of age should start with half a tablet taken up to three times daily, and this may be increased to one tablet up to three times daily if needed. Children aged 5 to 10 years should take half a tablet up to three times daily. Pheniramine Maleate tablets are not recommended for children under 5 years of age.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.

Key Interactions

Checker →