Indications
Oxaliplat, given together with infusional 5-fluorouracil and folinic acid, is indicated for the adjuvant treatment of stage III colon cancer in patients who have had the primary tumour completely removed by surgery, and for the treatment of advanced colorectal cancer.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Oxaliplatin converts nonenzymatically in body fluids to its active form once its labile oxalate group is displaced. This process forms several short-lived reactive species, including monoaquo and diaquo DACH platinum, which bind covalently to macromolecules. The drug forms both interstrand and intrastrand platinum-DNA crosslinks, joining the N7 positions of two adjacent guanines (GG), adjacent adenine-guanine pairs (AG), or guanines separated by an intervening nucleotide (GNG). These crosslinks block DNA replication and transcription, and the resulting cytotoxic effect is not specific to any phase of the cell cycle. In animal studies, oxaliplatin has shown activity against colon carcinoma. When combined with 5-fluorouracil, it produces greater antiproliferative effects, both in laboratory and animal studies, than either agent used alone, an effect seen across several tumor models, including HT29 (colon), GR (mammary), and L1210 (leukemia).
Pregnancy & Breastfeeding
Pregnancy Category D. Oxaliplatin may cause fetal harm when given to a pregnant woman, and there are no adequate, well-controlled studies of the drug in pregnant women. Women who could become pregnant should be advised to avoid pregnancy while receiving oxaliplatin treatment. It is not known whether oxaliplatin or its derivatives pass into human breast milk. Since many drugs are excreted in breast milk, and because nursing infants could face serious adverse effects from oxaliplatin, a decision should be made to discontinue either nursing or the drug, weighing how important the treatment is to the mother.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.