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Omega-3 Acid Ethyl Esters

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Indications

Myocardial Infarction Inflammation

Neomega is indicated as an adjunct to diet to reduce very high (>500mg/dl) triglyceride (TG) levels in adult patients and as an adjunct in secondary prevention in those who have had a myocardial infarction in the preceding 3 months. It is also indicated to help reduce the joint inflammation associated with mild arthritis, mood disorders & impulse control, age-related macular degeneration.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Omega-3-acid ethyl esters reduce triglyceride production by the liver, though this mechanism is not fully understood. They inhibit acyl-CoA: 1,2-diacylglycerol acyltransferase, reducing triglyceride synthesis and increasing peroxisomal beta-oxidation, which increases fatty acid metabolism. They also inhibit the release of fatty acids by competing for enzymes involved in triglyceride synthesis, increase triglyceride clearance by increasing lipoprotein lipase activity, and decrease production of VLDL-C.

Pregnancy & Breastfeeding

Pregnancy: Omega-3-acid ethyl esters should be used during pregnancy only if the potential benefit outweighs the potential risk to the fetus.

Breastfeeding: It is not known whether this medicine passes into human breast milk. It should therefore be used with caution in breastfeeding mothers.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: For hypertriglyceridaemia, it may be taken as a single dose of 4 capsules (4 gm), or as 2 capsules (2 gm) twice daily. For patients with a previous myocardial infarction, the usual dose is 1 capsule (1 gm) daily, taken with food. Patients should be placed on an appropriate lipid-lowering diet before starting Omega-3 Acid Ethyl Esters and should continue this diet throughout treatment. For joint inflammation associated with mild arthritis, the dose is 2.7 gm daily. For mood disorders, impulse control problems, and age-related macular degeneration, the dose is 1 capsule (1 gm) per day, or as directed by the registered physician.

Side Effects & Interactions

Side Effects

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