Ofloxacin

Adults: General dosage recommendations: The dose of ofloxacin depends on the type and severity of the infection. For adults, the dosage range is 200 mg to 800 mg daily. Doses of up to 400 mg may be taken as a single dose, preferably in the morning; larger doses should be split into two divided doses. Ofloxacin tablets should be swallowed with liquid, and should not be taken within two hours of magnesium- or aluminium-containing antacids or iron preparations, because these can reduce the absorption of ofloxacin. Enteric fever: Adults, 200 mg every 12 hours for 5 days; children, 15 mg/kg/day in 2 divided doses for 3 days. Shigellosis: 400 mg as a single dose. Multi-drug-resistant tuberculosis: 400 mg twice daily together with conventional anti-tuberculosis drugs. Lower respiratory tract infection: 400 mg daily, increased if necessary to 400 mg twice daily. Uncomplicated urinary tract infections: a single dose of 200/400 mg. Uncomplicated urethral and cervical gonorrhoea: a single dose of 400 mg. Non-gonococcal urethritis and cervicitis: 400 mg daily in single or divided doses. Complicated urinary tract infection: 200/400 mg/day for 7 days. Impaired liver function: Excretion of ofloxacin may be reduced in patients with severe hepatic dysfunction. Children: Ofloxacin is usually not indicated for use in children or growing adolescents. Elderly: No dosage adjustment is required in the elderly. Ofloxacin eye and ear drops. Eye: Instill 1 drop in the affected eye(s) every 2 to 4 hours for the first two days, then 4 times daily. Treatment should not continue for more than ten days. Ear: Instill 1 to 2 drops in the affected ear(s) twice daily or as needed.