Informational only — Not medical advice. Always consult a licensed healthcare provider.

MedBD
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Community data Updated 2 months ago
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Indications

Nitrofurantoin (NFT) is specifically indicated for the treatment and prophylaxis of urinary tract infections caused by susceptible strains of Escherichia coli, Enterococci, Staphylococcus aureus, Staphylococcus saprophyticus and certain susceptible strains of Klebsiella and Enterobacter species.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Nitrofurantoin is an antibacterial agent used specifically for urinary tract infections. It is highly soluble in urine, which it may turn brown. It works by inactivating or altering bacterial ribosomal proteins and other macromolecules. Nitrofurantoin has been shown to be active against the following bacteria: Gram-Positive Aerobes: Staphylococcus saprophyticus, coagulase-negative staphylococci (including Staphylococcus epidermidis), Enterococcus faecalis, Staphylococcus aureus, Streptococcus agalactiae, Group D streptococci, and viridans group streptococci. Gram-Negative Aerobes: Escherichia coli, Citrobacter amalonaticus, Citrobacter diversus, Citrobacter freundii, Klebsiella oxytoca, and Klebsiella ozaenae.

Pregnancy & Breastfeeding

Pregnancy Category B. Well-controlled studies in pregnant women are lacking, so this medicine should be used in pregnancy only if there is a clear need for it. Nitrofurantoin passes into breast milk in trace amounts. Because nursing infants under one month of age may be more susceptible to serious side effects from it, the mother and her doctor should decide together whether to stop breastfeeding or stop the medicine, weighing how important it is for her treatment.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Nitrofurantoin tablet (In adults): Uncomplicated urinary tract infections: 50-100 mg four times a day- the lower dosage level is recommended. Therapy should be continued for one week or for at least 3 days after sterility of the urine is obtained. For long-term suppressive therapy: In adults, a reduction of dosage to 50-100 mg at bedtime may be adequate. Nitrofurantoin capsule (In adults): Acute Uncomplicated Urinary Tract Infections (UTIs): 50 mg four times daily for 7 days. Long term suppression: 50-100 mg once a day. Prophylaxis: 50 mg four times daily for the duration of procedure and for three days thereafter. Nitrofurantoin SR capsule: Adults and Children over 12 years: One 100 mg capsule every 12 hours for seven days. Genito-urinary surgical prophylaxis: One capsule twice daily on day of procedure and for next 3 days. Nitrofurantoin suspension: Children: 5-7 mg/kg/day in four divided doses (contraindicated under one month of age). The average dose of Nintoin suspension for pediatric patients are as follows- 7 to 11 kg: ½ (2.5 ml) teaspoonfuls 4 times daily. 12 to 21 kg: 1 (5 ml) teaspoonfuls 4 times daily. 22 to 30 kg: 1½ (7.5 ml) teaspoonfuls 4 times daily. 31 to 41 kg: 2 (10 ml) teaspoonfuls 4 times daily. Therapy should be continued for one week or for at least 3 days after sterility of the urine is obtained. For long-term suppressive therapy in children, doses as low as 1 mg/kg per 24 hours, given in a single dose or in two divided doses, may be adequate.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.