Nalbuphine Hydrochloride

Adults: The usual recommended adult dose is 10 mg for a 70 kg individual, given by intramuscular or intravenous injection; this dose may be repeated every 3 to 6 hours as necessary. Dosage should be adjusted according to the severity of the pain, the physical condition of the patient, and other medications the patient may be receiving. For moderate to severe pain, the intravenous or intramuscular dose is 10 to 20 mg for a 70 kg patient, adjusted as required; for a child, up to 0.3 mg/kg, repeated once or twice as necessary. For preoperative anesthesia, the intravenous or intramuscular dose is 0.1 to 0.2 mg/kg. For obstetrical analgesia during labor and delivery, the intravenous dose is 0.3 to 1 mg/kg given over 10 to 15 minutes, with maintenance doses of 0.25 to 0.5 mg/kg given as a single intravenous administration as required. For intraoperative analgesia, the intravenous dose is 0.25 to 0.5 mg/kg at 30 minute intervals. For myocardial infarction, the dose is 10 to 20 mg by slow intravenous injection, repeated after 30 minutes if necessary. A larger dose is required when nalbuphine is used as a supplement to anesthesia than when it is used for analgesia alone. For children from 18 months to 15 years old, the usual dose is 0.2 mg/kg body weight, given preferably by intravenous or intramuscular injection. Maintenance doses may be given at intervals of 4 to 6 hours, or the dose may be determined by the physician.