Community data Updated 2 months ago

Milnacipran Hydrochloride

Serotonin-norepinephrine reuptake inhibitor (SNRI) Prescription

Indications

Neocipran tablets are used to manage fibromyalgia. Neocipran is not approved for use in children.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Milnacipran works as a potent inhibitor of neuronal norepinephrine and serotonin reuptake, acting on norepinephrine and serotonin in roughly a 1:3 ratio. Together these actions work synergistically to treat both depression and fibromyalgia, easing multiple fibromyalgia symptoms such as peripheral and central pain, low mood, and poor sleep and quality of life.

Pregnancy & Breastfeeding

Milnacipran has not been thoroughly studied in pregnant women, so its full risks during pregnancy remain unknown. In animal studies, rats given the drug during pregnancy showed an increased risk of fetal death. Milnacipran falls under pregnancy category C, meaning it may be prescribed to a pregnant woman if her physician determines that the potential benefits to her outweigh the possible risks to the unborn child.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: The recommended dose of Milnacipran HCI for adults is 100 mg per day, taken as 50 mg twice daily. Depending on how well the medicine works and how well it is tolerated, the dose may be built up gradually according to the following schedule: on Day 1, 12.5 mg taken once; on Days 2 to 3, 25 mg per day, taken as 12.5 mg twice daily; on Days 4 to 7, 50 mg per day, taken as 25 mg twice daily; and after Day 7, 100 mg per day, taken as 50 mg twice daily. Based on how the individual patient responds, the dose may be increased to 200 mg per day, taken as 100 mg twice daily. Doses above 200 mg per day have not been studied.