Informational only — Not medical advice. Always consult a licensed healthcare provider.

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Community data Updated 2 months ago
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Indications

MIF is indicated: As a medical alternative to surgical termination of intra-uterine pregnancy Softening and dilatation of the cervix uteri prior to surgical pregnancy termination Preparation for the action of prostaglandin analogues in the termination of pregnancy for medical reasons Labour induction for the expulsion of a dead fetus (fetal death in utero).

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Mifepristone is an antiprogestin, meaning it blocks the action of progesterone, a naturally produced hormone that prepares the inner lining of the uterus for implantation of a fertilized ovum and support of a growing embryo and placenta. The drug is taken orally in a prescribed dose during the first seven to nine weeks of pregnancy, and within two days the uterine lining begins to deteriorate, usually causing bleeding similar to that experienced during normal menstruation. Mifepristone is then followed by a dose (taken orally or as a vaginal suppository) of the synthetic prostaglandin Misoprostol, which stimulates the uterus to undergo contractions. The embryo and other uterine contents are then expelled in a process very similar to spontaneous abortion or miscarriage.

Pregnancy & Breastfeeding

Mifepristone is approved only for ending an early pregnancy, up to 49 days' gestation, and should not be used for any other purpose during pregnancy. Whether it passes into breast milk is not known, though many hormones with a similar structure do. Because its effects on a nursing infant are not established, breastfeeding mothers should talk to their doctor about whether to express and discard their milk for a few days after taking the medication.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: As a medical alternative to surgical termination of intra-uterine pregnancy in early pregnancy: a single oral dose of 600 mg Mifepristone is taken, followed 36 to 48 hours later by a prostaglandin analogue, either Misoprostol 400 mcg taken orally (for pregnancies up to 49 days) or Gemeprost 1 mg given vaginally (for pregnancies up to 63 days). For softening and dilatation of the cervix uteri before surgical termination of pregnancy: 200 mg Mifepristone is given, followed 36 to 48 hours later (but not later than that) by the surgical termination of pregnancy. As preparation for the action of prostaglandin analogues when terminating a pregnancy for medical reasons, in order to reduce the required doses of prostaglandin: a single oral dose of 600 mg Mifepristone is taken 36 to 48 hours before the scheduled prostaglandin administration, which is then repeated as often as needed. For induction of labour to expel a dead fetus (fetal death in utero): 600 mg of Mifepristone is taken as a single oral dose, once daily, for 2 consecutive days. Mifepristone alone brings about expulsion in around 60% of cases. If labour has not begun within 72 hours of the first Mifepristone dose, it should be induced using the usual methods. Use in children: safety and effectiveness in pediatric patients have not been established.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.