Indications
Micofun oral gel is used to treat oral and gastrointestinal candidiasis, to clear fungal colonization from the mouth and gastrointestinal tract, and to treat super infections caused by gram-positive bacteria. Micofun cream is used for dermatomycoses such as tinea pedis (athlete's foot), tinea corporis (tinea circinata), tinea manuum and tinea cruris caused by Trichophyton mentagrophytes, Trichophyton rubrum, Microsporum audouinii and Epidermophyton floccosum, as well as candidial infections, tinea versicolor, skin infections such as intertrigo, perianal infections, stomatitis angularis (cheilitis), balanoposthitis and otitis externa. Miconazole cream also has a very rapid alleviating effect on the pruritis that often accompanies these infections.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Pharmacodynamics: Miconazole is active against the common dermatophytes and yeasts, and also shows antibacterial activity against certain gram-positive bacilli and cocci. It works by inhibiting a demethylation step in the biosynthesis of ergosterol, the end-product of this pathway and the main sterol found in fungal cell membranes. By blocking ergosterol production, miconazole disrupts the fungal cell membrane, causing holes to form in it. Through these holes, essential cell constituents leak out, and the fungal cells eventually die.
Pharmacokinetics: Miconazole has low oral bioavailability (25-30%), as little of it is absorbed from the intestinal tract; however, it is absorbed systemically when given as an oral gel. Once absorbed, it binds extensively to plasma proteins (88.2%), mainly serum albumin, and to red blood cells (10.6%). Most of the absorbed drug is metabolized, with less than 1% excreted unchanged in the urine. Its terminal plasma half-life is 20-25 hours in most patients, and this elimination half-life remains similar in patients with impaired renal function.
Pregnancy & Breastfeeding
Miconazole oral gel has not been studied for safety during pregnancy, so it should be avoided if at all possible; where use is being considered, the potential risks need to be weighed against the expected benefit. Because many medicines pass into breast milk, Miconazole should be used with caution in nursing mothers.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.