Informational only — Not medical advice. Always consult a licensed healthcare provider.

Community data Updated 2 months ago

Indications

Micofun oral gel is used to treat oral and gastrointestinal candidiasis, to clear fungal colonization from the mouth and gastrointestinal tract, and to treat super infections caused by gram-positive bacteria. Micofun cream is used for dermatomycoses such as tinea pedis (athlete's foot), tinea corporis (tinea circinata), tinea manuum and tinea cruris caused by Trichophyton mentagrophytes, Trichophyton rubrum, Microsporum audouinii and Epidermophyton floccosum, as well as candidial infections, tinea versicolor, skin infections such as intertrigo, perianal infections, stomatitis angularis (cheilitis), balanoposthitis and otitis externa. Miconazole cream also has a very rapid alleviating effect on the pruritis that often accompanies these infections.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Pharmacodynamics: Miconazole is active against the common dermatophytes and yeasts, and also shows antibacterial activity against certain gram-positive bacilli and cocci. It works by inhibiting a demethylation step in the biosynthesis of ergosterol, the end-product of this pathway and the main sterol found in fungal cell membranes. By blocking ergosterol production, miconazole disrupts the fungal cell membrane, causing holes to form in it. Through these holes, essential cell constituents leak out, and the fungal cells eventually die.

Pharmacokinetics: Miconazole has low oral bioavailability (25-30%), as little of it is absorbed from the intestinal tract; however, it is absorbed systemically when given as an oral gel. Once absorbed, it binds extensively to plasma proteins (88.2%), mainly serum albumin, and to red blood cells (10.6%). Most of the absorbed drug is metabolized, with less than 1% excreted unchanged in the urine. Its terminal plasma half-life is 20-25 hours in most patients, and this elimination half-life remains similar in patients with impaired renal function.

Pregnancy & Breastfeeding

Miconazole oral gel has not been studied for safety during pregnancy, so it should be avoided if at all possible; where use is being considered, the potential risks need to be weighed against the expected benefit. Because many medicines pass into breast milk, Miconazole should be used with caution in nursing mothers.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Dosage Miconazole Oral Gel-Oropharyngeal candidosis- Infants 4-24 months: 1.25 ml (1⁄4 measuring spoon) of gel, applied 4 times day after meals. Adult and children 2 years of age and older: 2.5 ml (1⁄2 measuring spoon) of gel, applied 4 times a day after meals. Gastrointestinal tract candidosis- Infants (4 months of age or above): Children and adults who have difficulty swallowing tablets: 20 mg per kg body weight per day, in four divided doses. The daily dose should not exceed 250 mg (10 ml gel) four times daily. Missed Dose: Apply the missed dose as soon as you remember. In case of next dosing time, omit the misseddose and continue your usual course.Miconazole Cream: Sufficient Miconazole Cream should be applied to cover affected areas twice daily (morning and evening) in patients with tinea pedis, tinea cruris, tinea corporis and cutaneous candidiasis and once daily in patients with tinea versicolor. If Miconazole Cream is used in intertriginous areas it should be applied sparingly and smoothed in well to avoid maceration effects.Early relief of symptoms (2 to 3 days) is experienced by the majority of patients and clinical improvement may be seen fairly soon after treatment is begun.All lesions usually disappear after 2 to 5 weeks.Prolong treatment for 10 days to prevent relapse. However, Candida infections, tinea cruris and corporis should be treated for two weeks and tinea pedis for one month in order to reduce the possibility of recurrence.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.