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Lurasidone Hydrochloride

Atypical neuroleptic drugs Prescription
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Indications

Depression Schizophrenia

Lurasid is an atypical antipsychotic used to treat schizophrenia. It is also used for depressive episodes linked to Bipolar I Disorder (bipolar depression), either on its own or alongside lithium or valproate.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

The mechanism by which Lurasidone works in schizophrenia and bipolar depression is not fully known. However, its effectiveness in both conditions may be linked to its combined antagonism of central dopamine Type 2 (D2) and serotonin Type 2 (5HT2A) receptors.

Pregnancy & Breastfeeding

Pregnancy Category B. Lurasidone should only be used in pregnancy if the potential benefit to the mother outweighs the potential risk to the unborn child. Patients taking Lurasidone should be advised against breast-feeding.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Lurasidone should be taken with food, providing at least 350 calories, since taking it with food substantially increases how well it is absorbed. For schizophrenia, the recommended starting dose is 40 mg once daily, and no initial dose titration is required. The maximum recommended dose is 160 mg per day. For depressive episodes associated with Bipolar I Disorder, the recommended starting dose is 20 mg once daily, whether used alone or as an add on therapy with lithium or valproate, and no initial dose titration is required. The maximum recommended dose, whether used alone or as an add on therapy with lithium or valproate, is 120 mg per day. In moderate to severe renal impairment, the recommended starting dose is 20 mg per day, and the maximum recommended dose is 80 mg per day. In moderate to severe hepatic impairment, the recommended starting dose is 20 mg per day. The maximum recommended dose is 80 mg per day for moderate hepatic impairment and 40 mg per day for severe hepatic impairment. Safety and effectiveness in pediatric patients have not been established.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.