Indications
Chronic Idiopathic Constipation: Lubigut is indicated for the treatment of chronic idiopathic constipation in adults.Opioid-induced Constipation: Lubigut is indicated for the treatment of opioid-induced constipation in adults.Irritable Bowel Syndrome with Constipation: Lubigut is the only FDA approved drug for the treatment of irritable bowel syndrome with constipation in women >18 years old.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Lubiprostone is a locally acting chloride channel activator. It boosts the secretion of chloride-rich fluid into the intestine without changing sodium or potassium levels in the blood. It works by specifically activating ClC-2, a channel normally present in the apical membrane of the human intestinal lining. This rise in intestinal fluid secretion increases intestinal motility, which helps stool pass more easily and eases the symptoms of constipation. After a dose, lubiprostone and its metabolites are found only on the apical (luminal) side of the gastrointestinal lining. Its activation of ClC-2 also helps restore mucosal barrier function by rebuilding tight junction protein complexes. Symptom relief is typically felt within 24 hours.
Pregnancy & Breastfeeding
Pregnancy Category C. Lubiprostone should only be used during pregnancy if the potential benefit to the mother is judged to outweigh the possible risk to the unborn baby. It is not known whether Lubiprostone passes into human breast milk.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.