Informational only — Not medical advice. Always consult a licensed healthcare provider.

MedBD
বাং
Community data Updated 2 months ago

Loteprednol Etabonate

Ophthalmic Steroid preparations Prescription
Check interactions
🌐 বাংলায় দেখুন

Indications

Pain Viral Infection Acne Vulgaris Conjunctivitis Inflammation

0.5% ophthalmic suspension: Lotepin suspension is indicated for steroid-responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea and anterior segment of the eyeball, such as allergic conjunctivitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis and cyclitis. It is also effective in post-operative inflammation. 1% ophthalmic suspension: Lotepin suspension is indicated for steroid-responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea and anterior segment of the eyeball, such as allergic conjunctivitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis and cyclitis. It is also effective in post-operative inflammation. 0.5% ophthalmic ointment: Lotepin ointment is indicated for the treatment of steroid-responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea and anterior segment of the globe, such as allergic conjunctivitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis and uveitis. Lotepin is also indicated for the treatment of post-operative inflammation and pain following ocular surgery. 0.5% ophthalmic gel: Lotepin gel is indicated for the treatment of post-operative inflammation and pain following ocular surgery. It is also effective in steroid-responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea and anterior segment of the eyeball, such as allergic conjunctivitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis and cyclitis.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Corticosteroids work by damping down the inflammatory response, whatever the trigger, though they probably also slow the healing process somewhat. In practical terms, they reduce the swelling, fluid leakage, capillary widening, and migration of white blood cells that are part of inflammation, along with the proliferation of new capillaries and fibroblasts and the laying down of collagen and scar tissue.

Exactly how corticosteroids act in the eye isn't fully settled, but the leading theory is that they trigger the production of proteins called lipocortins, which block the enzyme phospholipase A2. Since this enzyme is what releases arachidonic acid from cell membrane phospholipids, and arachidonic acid is the raw material the body uses to make inflammatory mediators like prostaglandins and leukotrienes, blocking it this way is thought to curb inflammation at its source.

Pregnancy & Breastfeeding

Pregnancy Category C. No clinical data are available on pregnancies exposed to loteprednol etabonate, though animal studies have shown reproductive toxicity. Because the risk to humans is unknown, it should be used in pregnancy only if clearly necessary. It is also not known whether topical ophthalmic corticosteroids are absorbed into the bloodstream in amounts sufficient to appear in human milk, so loteprednol should be used with caution in nursing mothers.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: 0.5% ophthalmic suspension: For steroid responsive ocular inflammation, instill 1 drop of Loteprednol Ophthalmic Suspension into the conjunctival sac of the affected eye or eyes four times a day. For inflammation after surgery, instill 1 drop of Loteprednol Ophthalmic Suspension into the conjunctival sac of the operated eye or eyes four times a day, beginning 24 hours after surgery and continuing throughout the first two weeks after surgery. 1% ophthalmic suspension: For steroid responsive ocular inflammation, instill 1 drop of Loteprednol DS Ophthalmic Suspension into the conjunctival sac of the affected eye or eyes 2 times a day. For inflammation after surgery, instill 1 drop of Loteprednol DS Ophthalmic Suspension into the conjunctival sac of the operated eye or eyes 2 times a day, beginning 24 hours after surgery and continuing throughout the first two weeks after surgery. 0.5% ophthalmic ointment: Apply a small amount (approximately a 1/2 inch ribbon) into the conjunctival sac or sacs four times daily, beginning 24 hours after surgery and continuing throughout the first 2 weeks of the postoperative period. Ophthalmic gel: Instill one to two drops of Loteprednol Gel Sterile Ophthalmic Gel into the conjunctival sac of the affected eye four times daily, beginning the day after surgery and continuing throughout the first 2 weeks of the postoperative period. Use in children: Safety and effectiveness in pediatric patients have not been established. Geriatric use: No overall differences in safety and effectiveness have been observed between elderly and younger patients.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.