Informational only — Not medical advice. Always consult a licensed healthcare provider.

Community data Updated 2 months ago

Indications

Hypertension: Losart-P tablet is indicated for the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents, such as thiazide diuretics. Renal protection in type-2 diabetic patients with proteinuria: Losart-P tablet is indicated to delay the progression of renal disease in hypertensive type-2 diabetic patients with proteinuria, defined as a urinary albumin to creatinine ratio greater than 300 mg/g.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Losartan Potassium is the first non-peptide, orally active angiotensin II receptor blocker. It binds to the AT1 receptor found in many tissues (such as vascular smooth muscle, the adrenal gland, kidneys and heart) and reduces several important biological actions, including vasoconstriction and the release of aldosterone, which are responsible for hypertension.

Pregnancy & Breastfeeding

Pregnancy Category D. If Losartan Potassium is taken during the second or third trimester of pregnancy, the risk to the baby increases. It is not known whether Losartan Potassium passes into human breast milk. Since many drugs do pass into breast milk, and because of the possible risk of adverse effects on a nursing infant, a decision should be made whether to stop breastfeeding or stop the medicine, weighing how important the drug is to the mother.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: The usual starting and maintenance dose for most patients is 50 mg once daily. If 50 mg once daily does not lower blood pressure enough, 25 mg twice daily is recommended before the dose is increased. For patients with intravascular volume depletion (for example, those treated with high-dose diuretics), a starting dose of 25 mg once daily should be considered. Losartan Potassium can be given once or twice daily. The total daily dose ranges from 25 mg to 100 mg. Patients up to 75 years: No initial dosage adjustment is necessary for this group of patients. Patients over 75 years: There is currently limited clinical experience in this group; a lower starting dose of 25 mg once daily is recommended.

Side Effects & Interactions