Informational only — Not medical advice. Always consult a licensed healthcare provider.

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Community data Updated 2 months ago
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Indications

Nausea and Vomiting Anxiety Insomnia Cancer

Lorapam is used to treat anxiety states, including anxiety linked to phobic and obsessional conditions, and anxiety occurring alongside psychosomatic, organic, or psychotic illness. It is also used for insomnia associated with anxiety, nervousness, restlessness, nausea and vomiting related to chemotherapy and anticonvulsants, and as a premedicant before dental or general surgery or before investigative procedures that may cause discomfort. Lorapam is not recommended for anxiety states in children, but it may be used as a premedicant before surgery in children aged 5 to 13 years, at a dose of 0.05 mg/Kg. The dose of Lorapam tablet should be increased gradually when needed, to avoid adverse effects. When a higher dose is required, the evening dose should be increased before the daytime dose.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Lorazepam is a short-acting tranquilizer of the benzodiazepine group. It is an agonist at benzodiazepine receptors in the CNS. It exerts a depressant action on the CNS, which may be mediated by potentiating the inhibitory actions of GABA (gamma amino butyric acid) in the CNS. This will result in diminution of the ascending activating systems, particularly the serotonergic and noradrenergic pathway from brain stem or the mid-brain to the cerebral cortex.

Pregnancy & Breastfeeding

Safety of Lorazepam during pregnancy has not been established. Since treatment with this medicine is rarely urgent, it should almost always be avoided during this period.

It is not known whether oral Lorazepam passes into breast milk, as other benzodiazepine sedatives do. As a general precaution, breastfeeding should be avoided while taking this medicine, since many drugs are known to pass into breast milk.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Lorazepam is taken by mouth. For best results, the dose, how often it is taken, and how long treatment continues should be tailored to each patient's response. The usual range is 2 to 6 mg a day in divided doses, with the largest dose taken at bedtime, though the largest single dose may range from 1 to 10 mg a day. For anxiety, most patients need an initial dose of 2 to 3 mg a day, taken twice or three times daily. For elderly or frail patients, an initial dose of 1 to 2 mg a day in divided doses is recommended, adjusted as needed and tolerated. For insomnia, 1 to 2 mg is taken before bedtime; as a premedicant, 1 to 2 mg is given the night before surgery and again 1 to 2 hours before surgery. Lorazepam injection can be given intravenously or intramuscularly. For premedication in adults: 0.05 mg/kg (3.5 mg for an average 70 kg person), given by IV 30 to 45 minutes before the procedure, or by IM 60 to 90 minutes before. For acute anxiety in adults: 0.025 to 0.03 mg/kg (1.75 to 2.1 mg for an average 70 kg person), repeated every 6 hours. For status epilepticus in adults: 4 mg intravenously; in children: 2 mg intravenously. For intramuscular use, undiluted lorazepam injection should be given. For intravenous use, it must be diluted with an equal volume of a compatible solution, such as sterile water for injection, sodium chloride injection, or 5% dextrose injection. The rate of injection should not exceed 2 mg per minute.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.