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Insulin Lispro

Rapid Acting Insulin Prescription
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Indications

Type 2 Diabetes Mellitus Type 1 Diabetes Mellitus Diabetes Mellitus

Humalog 200 is an insulin analogue indicated for the treatment of diabetes mellitus to help control high blood sugar (hyperglycemia). It has a faster onset and a shorter duration of action than human regular insulin. Because of this, patients with type 1 diabetes should use Humalog 200 as part of a regimen that also includes a longer-acting insulin. In patients with type 2 diabetes, however, Humalog 200 may be used on its own, without a longer-acting insulin, when given together with sulfonylurea agents as combination therapy.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Insulin Lispro (insulin lispro, rDNA origin) is a human insulin analogue that is a rapid-acting, parenteral blood glucose-lowering agent. Chemically, it is Lys(B28), Pro(B29) human insulin analogue, made by reversing the amino acids at positions 28 and 29 on the insulin B-chain. Insulin Lispro is produced in a special non-pathogenic laboratory strain of Escherichia coli bacteria that has been genetically altered by adding the gene for insulin lispro. Its blood glucose lowering effect comes from the facilitated uptake of glucose after insulin binds to receptors on muscle and fat cells, along with the simultaneous inhibition of glucose output from the liver.

Pregnancy & Breastfeeding

Pregnancy Category B. All pregnancies carry a background risk of birth defects, loss, or other adverse outcomes regardless of drug exposure. This background risk is increased in pregnancies complicated by hyperglycemia and may be decreased with good metabolic control. It is essential for patients with diabetes or a history of gestational diabetes to maintain good metabolic control before conception and throughout pregnancy. In patients with diabetes or gestational diabetes, insulin requirements may decrease during the first trimester, generally increase during the second and third trimesters, and decline rapidly after delivery. Careful monitoring of glucose control is essential in these patients. Female patients should therefore be advised to tell their physicians if they intend to become, or if they become, pregnant while taking Insulin Lispro.

Nursing mothers: It is not known whether insulin lispro passes into human milk. Because many drugs are excreted in human milk, caution should be exercised when giving insulin lispro to a nursing mother. Insulin lispro use is compatible with breastfeeding, though nursing women with diabetes may need adjustments to their insulin doses.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Adults, subcutaneous (SC) injection: The dosing regimen should be individualised and adjusted according to the patient's blood glucose response. The usual range is approximately 0.5 to 1 unit/kg/day. Type 1 diabetes mellitus: Approximately one third of the total daily insulin requirement is given as SC insulin lispro, with a rapid acting or short acting, premeal insulin used to supply the remainder of the daily requirement. The usual daily maintenance range is 0.5 to 1 unit/kg/day in divided doses; patients who are not obese may need approximately 0.4 to 0.6 unit/kg/day, while obese patients may need approximately 0.8 to 1.2 units/kg/day. Type 2 diabetes mellitus: If control is inadequate on oral medication alone, an intermediate acting or long acting insulin is generally recommended, given SC at bedtime at approximately 10 units/day (or approximately 0.1 to 0.2 unit/kg/day). As an alternative, rapid acting formulations such as insulin lispro, given before meals, have also been used, with the dose adjusted carefully.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.