Insulin Aspart

Adults: Dosage of Insulin Aspart is individualized and determined by the physician according to the patient's needs. In patients with type 2 diabetes, Insulin Aspart can be used as monotherapy or combined with oral antidiabetic drugs (OADs) when blood glucose is not adequately controlled by those oral antidiabetic drugs alone. For patients with type 2 diabetes, the recommended starting dose is 6 IU at breakfast and 6 IU at dinner (evening meal). Insulin Aspart can also be started once daily at 12 IU with dinner (evening meal). When Insulin Aspart is used once daily, it is generally recommended to switch to twice daily dosing once the dose reaches 30 units, splitting it into equal breakfast and dinner doses. If twice daily dosing leads to recurrent daytime hypoglycaemic episodes, the morning dose can be split into morning and lunchtime doses, giving thrice daily dosing. The dose should not be increased if hypoglycemia has occurred within the previous three days. Dose adjustments can be made once a week until the target HbA1c is reached. In patients with type 1 diabetes, individual insulin requirements are usually between 0.5 and 1.0 IU/kg/day, and Insulin Aspart may meet this requirement fully or in part. When switching a patient from biphasic human insulin to Insulin Aspart, begin with the same dose and regimen, then adjust according to individual needs, following the titration guidelines in the table above. Insulin Aspart can be used in elderly patients; however, experience with its use in combination with OADs in patients older than 75 years is limited.