Heparin Sodium

Adults: Administer Heparin Sodium Injection by Intermittent IV Injection, IV Infusion, Or Deep Subcutaneous Injection. Heparin Sodium Injection is not intended for Intramuscular (IM) use.Heparin sodium is not effective by oral administration and should not be given orally.Parenteral drug products should be inspected visually for particulate matter and discolouration prior to administration. Use of a final filter is recommended during administration of all parenteral solutions, where possible.Therapeutic Anticoagulant Effect with Full-Dose Heparin- Deep Subcutaneous (Intrafat) Injection Initial Dose 333 units/kg subcutaneously Use a different site for each injection Every 12 hours 250 units/kg subcutaneously Intermittent Intravenous Injection Initial Dose 10,000 units Intermittent Intravenous Injection Every 4 to 6 hours 5,000 to 10,000 units Continuous Intravenous Infusion Initial Dose 5,000 units by intravenous injection Continuous Intravenous Infusion Continuous 20,000 to 40,000 units/24 hours *Based on 150 lb. (68 kg) patient Surgery of the Heart and Blood Vessel- Intravascular via Total Body Perfusion Initial Dose ≥ 150 units/kg; adjust for longer procedures Use in Extracorporeal TherapyThe concentration of 2 units/mL will suffice to prevent clotting on initiation of extracorporeal therapy by priming the devices with this solution. NOTE: A proper and effective heparinisation schedule must be initiated in the patient before and maintained throughout the procedures to prevent subsequent clotting and blood path obstruction. The particular manufacturer's directions for use of the dialyser or other extracorporeal apparatus must be referred to. The direction sheets for the use of therapeutic dosage forms of heparin must equally be referred to and adjusted to a given patient’s condition and response to achieve sustained, effective anticoagulation within clinically safe parameters. Both intermittent and continuous infusion of 5000, 10000 or 20000 units are employed for this purpose and are unrelated to the low dose heparin in this preparation that is directed at preparing the apparatus for initial use.Maintenance of Catheter PatencyAlthough the rate for infusion of the 2 units/mL formulation is dependent upon age, weight, clinical condition of the patient and theprocedure being employed, an infusion rate of 3 mL/hour has been found to be satisfactory.Periodic platelet counts; hematocrits, and tests for occult blood in stool are recommended during the entire course of heparin therapy, regardless of the route of administration.Because dosages of this drug are titrated to response, no additives should be made to heparin sodium injection.