Indications
Halosin is a volatile anaesthetic agent suitable for inducing and maintaining anaesthesia across all types of surgery, in patients of any age.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
When inhaled, Halothane is absorbed through the alveoli into the bloodstream. It then circulates through the body to its principal site of action, the brain. There, Halothane causes a progressive depression of the central nervous system, beginning with the higher centers (cerebral cortex) and spreading to the vital centers in the medulla. This depression is reversible, though its mode of action, like that of all anaesthetic agents, is unknown.
Halothane has a relatively low solubility in blood, so alveolar and blood concentrations equilibrate rapidly. The triexponential decline in Halothane blood concentrations after administration ends is thought to represent distribution into three compartments: the vessel rich group (brain, heart, liver), the musculature and the adipose tissue. Approximately 80% of the inhaled Halothane is eliminated unchanged by the lungs. The remaining 20% is metabolized in the liver, through oxidative pathways and, under hypoxic conditions, reductive pathways. The main metabolites are trifluoroacetic acid, bromide and chloride salts (from the oxidative pathway) and fluoride salts (from the reductive pathway). Concentrations of these metabolites peak 24 hours after surgery and are cleared by renal excretion over the following week.
Pregnancy & Breastfeeding
Although animal experimental data cannot be directly applied to humans, it is prudent to avoid inhalation general anaesthesia during early pregnancy unless its use is essential. Well-controlled studies of Halothane in breastfeeding women are lacking. Halothane has been detected in the breast milk of lactating mothers, but its effect on breastfed infants has not been established. Nonetheless, Halothane has been in widespread use for over 30 years without apparent adverse consequences.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.