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Glipizide

Sulfonylureas Prescription
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Indications

Type 2 Diabetes Mellitus Type 1 Diabetes Mellitus Diabetes Mellitus

Diapizi is indicated as an adjunct to diet for controlling high blood sugar and its related symptoms in the treatment of non-insulin-dependent diabetes mellitus (NIDDM, type II) when diet modification alone has not proved effective. In some patients already receiving insulin, adding Diapizi may allow the daily insulin dose to be reduced. Diapizi should be viewed by both physician and patient as a treatment that supplements diet, not as a replacement for it or a convenient way to avoid dietary discipline. Short-term use of Diapizi may also be appropriate if diet control alone brings only a temporary improvement in blood glucose levels. During maintenance therapy, if blood glucose is no longer being adequately controlled, Diapizi should be discontinued.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Glipizide lowers blood glucose by stimulating the release of insulin from the pancreas, an effect dependent upon functioning beta cells. The extrapancreatic effects of Glipizide are increase in insulin sensitivity and decrease in hepatic glucose production.

Pregnancy & Breastfeeding

Pregnancy: Glipizide should be used during pregnancy only if the potential benefit justifies the potential risk to the foetus. Prolonged, severe hypoglycaemia (lasting 4 to 10 days) has been reported in newborns whose mothers were taking a sulphonylurea (e.g., Glipizide) at the time of delivery. For this reason, if Glipizide is used during pregnancy, it should be stopped at least one month before the expected date of delivery.

Lactation: It is not known whether Glipizide passes into human breast milk, although some other sulphonylurea drugs are known to do so. Breastfeeding is therefore not recommended while taking this medication.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Like any other oral hypoglycaemic agent, dosage of Glipizide is not fixed and may be adjusted through periodic monitoring of blood glucose level. Short term administration of Glipizide may be sufficient during periods of transient loss of control of blood glucose in patients, usually controlled well on diet.In general, Glipizide should be given approximately 30 minutes before a meal to achieve the maximum reduction in postprandial hyperglycaemia. Initial dose: The recommended starting dose is 5 mg, given before breakfast. Geriatric patients or those with liver disease may be started on 2.5 mg. Dosage adjustments: Dosage adjustment may be done at intervals of several days by an increment of 2.5-5 mg, as determined by blood glucose response. If response to a single dose is not satisfactory, dividing that dose might prove effective. The maximum recommended once daily dose is 15 mg. Doses above 15 mg should ordinarily be divided and given before meals of adequate calorie content. The maximum recommended total daily dose is 40 mg. Maintenance: Some patients may be effectively controlled on a once daily regimen, while others show better response with divided dosing. Total daily dose above 30 mg have been safely given on bid basis to long term patients. Patients can usually be stabilized on a dosage ranging from 2.5 to 30 mg daily. In elderly, debilitated or malnourished patients, and patients with impaired renal or hepatic function: The initial and maintenance dosing should be conservative to avoid hypoglycaemic reactions.Patients receiving insulin: Many stable non-insulin-dependent diabetic patients receiving Insulin may be safely placed on Glipizide if the physician decides to do so.Patients receiving other oral hypoglycaemic agents: As with other sulphonylurea, no transition period is necessary while transferring patients to Glipizide. Patients should be observed carefully for any possible hypoglycaemic effect due to overlapping of drug effects.Pediatric Use: Safety and effectiveness in children have not been established.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.