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Gentamicin + Hydrocortisone Acetate

Hydrocortisone & Combined preparations Prescription
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Indications

Otitis Media

Gentabac HC is used to treat chronic suppurative otitis media and otitis externa, and can be used preventively for otitis externa after an ear injury. The ear drops are also used after mastoid surgery, applied locally to infected mastoid cavities during recovery.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Gentamicin is an aminoglycoside antibiotic with bactericidal activity against many Gram-negative bacteria and some Gram-positive strains. It is actively transported across the bacterial cell membrane, where it binds to a specific receptor protein on the 30S subunit of bacterial ribosomes. This disrupts the initiation complex formed between mRNA and the 30S subunit, blocking protein synthesis. As a result, DNA may be misread, leading to the production of nonfunctional proteins, while existing polyribosomes break apart and lose their ability to make protein. Hydrocortisone, for its part, reduces the formation, release, and activity of the body's natural inflammatory mediators and also modifies the immune response.

Pregnancy & Breastfeeding

Pregnancy: No adequate and well controlled studies have been performed in pregnant women. Topical administration of any corticosteroid to pregnant animals can cause abnormalities of foetal development. Caution should be exercised when this Ear Drops is used by a pregnant woman.Nursing Mothers: This Ear Drops should be administered to a nursing woman only after careful assessment of the potential risks and benefits.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Dosage for Middle Ear Infection: Instill 2 to 4 drops in the affected ear three to four times a day and at night, or more often if needed. Warm the suspension by holding the bottle in the hand for one or two minutes, since instilling a cold suspension may cause dizziness. The patient should lie down with the affected ear facing upward, and the drops should then be instilled. The tragus should then be pumped 5 times by pressing inward to help the drops penetrate into the middle ear. This position should be held for two minutes. Repeat for the opposite ear if necessary. Discard any unused portion once treatment is finished. For Ear Canal Infection: Instill 2 to 4 drops in the affected ear three to four times a day and at night, or more often if needed. Warm the suspension by holding the bottle in the hand for one or two minutes, since instilling a cold suspension may cause dizziness. The patient should lie down with the affected ear facing upward, and the drops should then be instilled. This position should be held for two minutes to help the drops penetrate into the ear canal. Repeat for the opposite ear if necessary. Discard any unused portion once treatment is finished.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.