Indications
Gelicon is a hypolipidemic medicine used alongside diet control. It is prescribed for type IIa, type IIb, type III, type IV and type V hyperlipoproteinemia.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Gemfibrozil is an anti-lipemic agent that lowers serum triglycerides in both healthy individuals and patients with hyper-triglyceridemia. It reduces very low-density lipoprotein (VLDL) triglyceride concentration and, to a lesser extent, LDL triglyceride concentration, while HDL-triglyceride is usually lowered slightly. It typically raises the HDL-cholesterol fraction in healthy individuals and patients with hyperlipoproteinemia, an effect that may help slow the progression of atherosclerosis and reduce the risk of coronary heart disease.
Gemfibrozil also inhibits synthesis of the VLDL carrier apolipoprotein B, which leads to decreased VLDL production. The mechanism by which it raises HDL concentration is not known. It inhibits lipolysis of fat in adipose tissue and reduces hepatic uptake of plasma free fatty acids, thereby lowering hepatic triglyceride production.
Gemfibrozil is rapidly and completely absorbed from the gastrointestinal tract, reaching peak plasma concentration within 1 to 2 hours and having a half-life of about 1.5 hours. About 70% of a dose is excreted in the urine, with only a small amount excreted in the faeces.
Pregnancy & Breastfeeding
Safety in human pregnancy has not been firmly established, and it isn't known whether gemfibrozil passes into breast milk. As with most medicines, it's generally best to avoid gemfibrozil during pregnancy and while breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.