Indications
Refolic is used to treat folic acid deficiency and megaloblastic anemia, including anemias linked to poor nutrition, pregnancy, infancy, or childhood.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Folic acid has no biological activity of its own; the body converts it, via dihydrofolate reductase (DHFR), into tetrahydrofolic acid and methyltetrahydrofolate. These active forms are carried into cells by receptor-mediated endocytosis, where they support normal red blood cell formation, help build the purine and thymidylate building blocks of nucleic acids, assist in converting one amino acid into another, add methyl groups to tRNA, and help generate and put formate to use. With vitamin B12 acting as a cofactor, folic acid can also bring down elevated homocysteine levels by converting homocysteine back to methionine through the enzyme methionine synthetase.
Pregnancy & Breastfeeding
No special precautions are known.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.
Key Interactions
Checker →- Methotrexate
- Dobutamine Hydrochloride
- Carbonyl Iron + Folic Acid + Zinc Sulfate
- 6s-5-Methyltetrahydrofolate [Bio-Active Folate]
- Carbonyl Iron + Folic Acid + Zinc Sulfate + Vitamin B Complex + Vitamin C
- Phenytoin Sodium
- Multivitamin [Vitamin B complex + Vitamin C]
- Sulfasalazine
- Carbonyl Iron + Folic Acid
- Vitamin B12 + Elemental Iron + Folic Acid
- Multivitamin [water & fat soluble] + 5% Dextrose
- Multivitamin [water & fat soluble] + Normal Saline