Informational only — Not medical advice. Always consult a licensed healthcare provider.

MedBD
বাং
Community data Updated 2 months ago
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Indications

Vertigo

Short-term treatment of climacteric complaints occurring after the cessation of monthly bleeding, or of deficiency symptoms following oophorectomy or radiological castration for non-cancerous conditions, such as hot flushes, sweating episodes, sleep disturbances, low mood, irritability, headaches, and dizziness. Gynova also has a favourable effect on bladder irritation, which is not an infrequent occurrence during the climacteric period, and on signs of thinning of the skin and mucous membranes, particularly in the genital region, which normally occur with advancing age.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Endogenous estrogens are largely responsible for the development and maintenance of the female reproductive system and secondary sexual characteristics. Although circulating estrogens exist in a dynamic equilibrium of metabolic interconversions, estradiol is the principal intracellular human estrogen and is substantially more potent than its metabolites, estrone and estriol, at the receptor level.

Pregnancy & Breastfeeding

Pregnancy category B3. Estradiol should not be used during pregnancy, and if pregnancy occurs while a woman is taking it, treatment should be stopped right away. In animal studies, giving pregnant animals high doses of synthetic oestrogens led to urogenital malformations in their offspring, though it is not clear how relevant these findings are to the clinical use of 17β-oestradiol in humans. Estradiol should also not be used while breastfeeding.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Hormone therapy should only be continued for as long as the relief of severe symptoms outweighs the risk. Before starting or restarting HRT, and periodically afterward, a complete medical history should be taken and a physical examination carried out. How often and in what detail these checks are done should follow established practice guidelines, generally with a review every 6 months, adapted to the individual woman. This should generally cover the pelvic organs (including routine cervical cytology), the abdomen, the breasts and blood pressure. Whether treatment should continue needs to be reconsidered at each review. Unless the doctor has prescribed otherwise, 1 Estradiol tablet is taken daily, swallowed whole with a little liquid. Each pack covers 30 days, and treatment is continuous, so the next pack is started right after the previous one without a break. It does not matter what time of day the tablet is taken, but once a particular time has been chosen, it should be kept to every day. If a tablet is forgotten at the usual time, it can still be taken within the next 12 to 24 hours. If treatment is interrupted for longer than this, irregular bleeding may occur. Treatment can be started at any time, provided pregnancy has been ruled out. Using unopposed oestrogens at high doses or for a long time during the climacteric may raise the risk of endometrial carcinoma, so endometrial hyperplasia needs to be avoided during unopposed oestrogen treatment. For this reason, a progestogen must be added for the last 10 to 14 days of each month of treatment. As a general rule, Estradiol treatment should be stopped every 6 months to check whether the symptoms being treated are still present. It is essential to follow the dosage schedule set by the doctor and to keep all appointments for gynaecological check-ups.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.