Indications
Erosil is highly effective in the treatment of a wide variety of clinical infections. Upper respiratory tract infections: Tonsilitis, Peritonsillar abscess, Pharyngitis, laryngitis, Sinusitis. Secondary infections in colds and influenza. Lower respiratory tract infections ... Read moreErosil is highly effective in the treatment of a wide variety of clinical infections. Upper respiratory tract infections: Tonsilitis, Peritonsillar abscess, Pharyngitis, laryngitis, Sinusitis. Secondary infections in colds and influenza. Lower respiratory tract infections: Tracheitis, acute and chronic bronchitis. Ear infections: Otitis media, otitis externa, mastoiditis. Eye infections: Blepharitis, established trachoma. Skin and Soft tissue infections: Boils and carbuncles, impetigo, abscesses, pustular acne, paromychia, cellulitis, erysipelas. Gastrointestinal tract infections: Cholecystitis, staphylococcal enterocolitis. Prophylaxis: Pre and post-operative, trauma, burns, rheumatic fever. Other infections: Osteomyelitis, diptheria, scarlet fever, whooping cough.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Erythromycin inhibits microsomal protein synthesis in susceptible organisms by inhibiting the translocation process. Specific binding to the 50S subunit or 70S ribosome occurs in these organisms but there is no binding to the stable 80S mammalian ribosome. Erythromycin is active against many Grampositive bacteria, some Gram-negative bacteria and against mycoplasmas and chlamydia.Absorption: Erythromycin base is destroyed by acid and is therefore administered in the form of stable ester. The rates of absorption of the base and esters are diminished by the presence of food. The stearate is hydrolyzed in the intestine and the free erythromycin absorbed. Blood concentration: After an oral dose of 500 mg. of the base of stearate, peak serum concentrations of 0.9 to 1.4 or 0.4 to 1.8 mg/ml. respectively are attained in 1 to 4 hours. Half-life: The serum half-life is 1.2 to 4 hours. In subjects with oliguria, the half-life is about 5 hours.Distribution: Erythromycin is widely distributed throughout body tissue and fluids with some retention in the liver and spleen, protein binding of erythromycin base is 73%. Erythromycin enters the cerebrospinal fluid when the meninges are inflamed. It also crosses the placenta and is excreted in the milk.Excretion: 5 to 15 % of the dose of erythromycin is excreted in the urine and large amounts of the unchanged active substance are excreted in the bile.
Pregnancy & Breastfeeding
Clinical and laboratory studies have not shown any evidence of birth defects or toxicity in humans. Even so, erythromycin should be used with caution in pregnant and breastfeeding women, as it crosses the placenta and passes into breast milk.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.