Informational only — Not medical advice. Always consult a licensed healthcare provider.

MedBD
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Community data Updated 2 months ago

Diphenhydramine Hydrochloride

Sedating Anti-histamine Prescription
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Indications

Allergic Rhinitis Fever Parkinson's Disease Nausea and Vomiting Eczema Urticaria Insomnia Allergy Conjunctivitis

Rymin syrup is used to treat allergic conditions such as hay fever, allergic rhinitis, urticaria, angioedema, atopic dermatitis, contact dermatitis, gastrointestinal allergy, pruritus, physical allergies, reactions to injected contrast media, reactions to therapeutic preparations and allergic transfusion reactions. It is also used for postoperative nausea and vomiting and for motion sickness. Rymin syrup may also be used to treat certain forms of parkinsonism and certain types of allergic conjunctivitis. It is sometimes used as a night-time sleep aid and for the short-term management of insomnia.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Diphenhydramine has anti-histaminic (H1-receptor), anti-emetic, anti-vertigo, sedative and hypnotic properties. Its anti-histamine action works by blocking the spasmogenic and congestive effects of histamine, competing with histamine for H1 receptor sites on effector cells and preventing (though not reversing) responses mediated by histamine alone. Such receptor sites may be found in the gut, uterus, large blood vessels, bronchial muscles, and elsewhere. Its anti-emetic action comes from inhibiting the medullary chemoreceptor trigger zone. Its anti-vertigo action comes from a central antimuscarinic effect on the vestibular apparatus and on the integrative vomiting center and medullary chemoreceptor trigger zone of the midbrain.

Pregnancy & Breastfeeding

Safety in pregnancy and breastfeeding has not been firmly established. If use is being considered during these periods, the potential benefits should be weighed carefully against any possible risks.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: As an antihistamine and antitussive, the tablet dose for adults is 25 mg to 50 mg taken 3 to 4 times daily, while children aged 10 years or over take 25 mg 3 or 4 times daily or as directed by the physician. For the syrup, children under 2 years take 2.5 mL every 4 to 6 hours, children aged 2 to under 6 years take 5 mL every 4 to 6 hours, children aged 6 to 12 years take 10-20 mL every 4 to 6 hours, and adults and children aged 12 years or over take 10-20 mL every 4 to 6 hours. As a sleep aid, adults and children over 12 years take 50 mg at bedtime.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.