Informational only — Not medical advice. Always consult a licensed healthcare provider.

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Community data Updated 2 months ago
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Indications

Epilepsy Anxiety Insomnia

Selium is used for the short term treatment of mild to moderate anxiety, along with symptoms such as excitation, agitation, fear, and aggressiveness. It may also be prescribed for anxiety reactions brought on by stressful conditions, anxiety states with physical symptoms, acute alcohol withdrawal, status epilepticus, premedication before surgical procedures, febrile convulsions, and insomnia in hospitalized patients. Selium nasal spray is indicated for the acute treatment of intermittent, stereotypic episodes of frequent seizure activity, such as seizure clusters or acute repetitive seizures, that are distinct from a patient's usual seizure pattern, in patients with epilepsy aged 6 years and older.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Diazepam binds to a specific site on the GABA receptor and boosts the effect of GABA, which works by opening chloride ion channels into cells. Taken by mouth, diazepam is absorbed rapidly and completely, with plasma levels peaking within 15-90 minutes. Its average plasma half-life is 30 hours, and it is 98-99% bound to plasma proteins. The liver metabolizes diazepam, and only traces of the unchanged drug appear in urine; a very small portion of its metabolites passes through the bile into the intestine and leaves the body in the feces. Given rectally as a suppository, diazepam is also well absorbed, with plasma levels peaking within 1.5-2 hours.

Pregnancy & Breastfeeding

Diazepam and its breakdown products (metabolites) can cross the placenta and are also excreted into breast milk. For this reason, it's best avoided during pregnancy and while breastfeeding unless there's no suitable alternative. It falls under US FDA pregnancy category D.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Oral use for anxiety: 2 mg three times a day, increased if necessary up to 15 to 30 mg daily in divided doses. Elderly or debilitated patients should be given half the usual adult dose. For insomnia linked with anxiety: 5 to 15 mg at bedtime. For night terrors and sleepwalking in children: 1 to 5 mg at bedtime. Injection, given into a large vein at a rate below 5 mg per minute: for severe acute anxiety, control of acute panic attacks, and acute alcohol withdrawal, 10 mg, which may be repeated if necessary after not less than 4 hours. For febrile convulsion in children: a slow intravenous dose of 250 mcg per kg. Rectal use in children: a dose of 500 mcg per kg, up to a maximum of 10 mg, repeated if necessary. Nasal spray: the recommended dose of Diazepam nasal spray is 0.2 mg per kg or 0.3 mg per kg, depending on the patient's age and weight. A second dose, if needed, may be given at least 4 hours after the first. No more than 2 doses should be used to treat a single episode. Diazepam nasal spray should be used to treat no more than one episode every five days and no more than five episodes per month.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.