Indications
Cybine may be used on its own or together with other chemotherapy medicines. It is indicated for inducing remission of leukaemia, particularly acute myeloid leukaemia, in adults and children. Cybine has also been used to induce remission in acute lymphocytic leukaemia, chronic myeloid leukaemia and erythroleukaemia, and in the treatment and maintenance therapy of meningeal leukaemia and other meningeal neoplasms. Children with non-Hodgkin's lymphoma have benefited from a combination drug programme (LSA2L2) that includes Cybine.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Cytarabine is an antineoplastic agent. A synthetic pyrimidine nucleoside, it is converted inside cells to its active form, cytarabine triphosphate. The exact mechanism is not fully understood, but this metabolite appears to inhibit DNA synthesis by blocking DNA polymerase, and its action is cell-cycle specific. Cytarabine also has immunosuppressant properties and has shown antiviral activity in vitro.
Pregnancy & Breastfeeding
During pregnancy, cytarabine is suspected of causing, or being able to cause, an increased rate of fetal malformations or irreversible harm, and it may also carry other adverse pharmacological effects. Because it has been shown to be teratogenic in some animal species, it should not be used during pregnancy, particularly in the first trimester, and should be avoided in women who may become pregnant. Whether cytarabine passes into human breast milk is not known. Women should be advised not to breastfeed during treatment with cytarabine, given the potential risk to the infant.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.