Informational only — Not medical advice. Always consult a licensed healthcare provider.

MedBD
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Community data Updated 2 months ago
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Indications

Hypertension

Clonipres ER is used to treat hypertension, either on its own or alongside another anti-hypertensive medicine. It is also used for menopausal flushing, opioid withdrawal, and alcohol withdrawal syndrome. As an extended-release tablet, Clonipres ER is also used alone to treat attention deficit hyperactivity disorder (ADHD).

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Clonidine hydrochloride works by stimulating alpha adrenoceptors in the brain stem. With the immediate-release form, blood pressure begins to fall within 30 to 60 minutes of taking a dose, reaching its lowest point 2 to 4 hours later. It does not meaningfully affect renal blood flow or the glomerular filtration rate, and because normal postural reflexes remain intact, symptoms related to standing up (orthostatic symptoms) are mild and uncommon.

Pregnancy & Breastfeeding

Pregnancy Category C. For this reason, Clonidine Hydrochloride is generally best avoided during pregnancy. It does pass into breast milk, so it should be used with caution in nursing mothers.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Adult: The dose of Clonidine Hydrochloride must be adjusted according to the patient's individual blood pressure response. Initial dose: 0.1 mg twice a day, taken in the morning and at bedtime. Elderly patients may benefit from a lower initial dose. Maintenance dose: further increments of 0.1 mg per day may be made at weekly intervals if necessary, until the desired result is achieved. The therapeutic dose most commonly employed has ranged from 0.2 mg to 0.6 mg per day, given in divided doses. In renal impairment, the dose of Clonidine Hydrochloride must be adjusted according to the degree of impairment, and the patient should be monitored carefully. For attention deficit hyperactivity disorder, Clonidine IR 5 mcg/kg/day or Clonidine ER 0.1 mg/day may be given for 8 weeks. For menopausal flushing, 0.1 mg to 0.4 mg daily may be given. For alcohol withdrawal, 0.3 to 0.6 mg may be given every 6 hours, or as directed by the physician. Use in children and adolescents: safety and effectiveness in pediatric patients have not been established in adequate and well controlled trials.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.