Clobetasol Propionate + Neomycin Sulphate + Nystatin

Clobetasol Propionate is a very potent corticosteroid. It is prescribed to treat severe inflammatory skin disorders such as eczema and psoriasis that have not responded to weaker corticosteroids. Neomycin Sulphate is an antibiotic of the aminoglycoside type and is used to treat bacterial infections. Nystatin is an antifungal that kills fungi and yeasts by interfering with their cell membranes. The mechanism of topical steroids like Clobetasol, in general, is not well understood. However, Clobetasol Propionate is a highly active corticosteroid with topical anti-inflammatory activity. Its major effect on the skin is a nonspecific anti-inflammatory response, due partly to vasoconstriction and a decrease in collagen synthesis. Neomycin binds to the ribosomal 30s and 50s subunits of susceptible bacteria and inhibits protein synthesis. It also causes the genetic codes of the mRNA template to be misread, so that incorrect amino acids are incorporated into the growing polypeptide chain. Nystatin acts by binding to sterols in the fungal cell membrane, changing its permeability and allowing intracellular components to leak out.