Chloramphenicol + Lidocaine Hydrochloride
Indications
Treats acute bacterial ear infections.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Chloramphenicol inhibits bacterial protein synthesis by binding to the 50S subunit of the bacterial ribosome, blocking peptide bond formation by peptidyl transferase. It acts both bacteriostatically and bactericidally against H. influenzae, N. meningitidis, and S. pneumoniae.
Lidocaine is an amide-type local anaesthetic. It stabilises the neuronal membrane and blocks sodium ion movement, which is needed for impulse conduction. In the heart, lidocaine reduces ventricular depolarisation during diastole and lowers automaticity in the His-Purkinje system. It also shortens the duration of the action potential and the effective refractory period.
Pregnancy & Breastfeeding
Pregnancy Category C & B. In animal studies, the drug has been shown to harm the fetus, and there are no adequate, well-controlled studies in pregnant women, but its potential benefits may justify use in pregnant women despite the possible risks. Alternatively, animal studies have not shown a risk to the fetus, though human data remain limited, or animal studies did show harm while adequate, well-controlled studies in pregnant women found no risk to the fetus in any trimester.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.