Indications
Urinide is used to relieve edema (fluid buildup) linked to congestive heart failure, as well as liver and kidney disease, including nephrotic syndrome.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Bumetanide is a loop diuretic known for acting quickly and for a relatively short duration. Studies show that a 1 mg dose delivers roughly the same diuretic effect as about 40 mg of furosemide, making it a considerably more potent medicine milligram for milligram.
It works mainly at the ascending limb of the loop of Henle, where it blocks the reabsorption of both sodium and chloride. There is also evidence that Bumetanide acts on the proximal tubule of the kidney: because phosphate is normally reabsorbed largely at this site, the increased loss of phosphate in the urine seen during Bumetanide-induced diuresis points to this extra site of action. This effect on the proximal tubule does not appear to result from inhibiting carbonic anhydrase. Bumetanide does not appear to have any meaningful effect on the distal tubule.
Pregnancy & Breastfeeding
Pregnancy Category C. Well-controlled studies in pregnant women have not been done, so its safety in pregnancy has not been firmly established. It is also not known whether this medicine passes into breast milk.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.