Indications
Pulmicort nasal spray is recommended for the prophylaxis and treatment of seasonal and perennial allergic rhinitis, as well as the prophylaxis and treatment of vasomotor rhinitis. It also provides symptomatic relief from nasal polyposis and helps prevent nasal polyps from recurring after polypectomy.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Budesonide is a synthetic corticosteroid with potent glucocorticoid activity and weak mineralocorticoid activity. It has roughly 200 times greater affinity for the glucocorticoid receptor and about 1000 times greater topical anti-inflammatory potency than cortisol. Corticosteroids have been shown to have a wide range of inhibitory effects against multiple cell types (such as mast cells, eosinophils, neutrophils, macrophages, and lymphocytes) and mediators (such as histamine, eicosanoids, leukotrienes, and cytokines) involved in allergy related inflammation.
Pregnancy & Breastfeeding
Pregnancy: The FDA has placed inhaled budesonide in pregnancy category B. In animal studies, high inhaled doses have not shown the drug to be teratogenic. Even with those animal findings, the chance of fetal harm looks remote when the inhaled form is used during pregnancy. Still, because human studies cannot fully rule out risk, inhaled budesonide should be used in pregnancy only when it is clearly needed.
Lactation: Only minute amounts of inhaled budesonide pass into breastmilk, so an infant's exposure is negligible. Reviewers and an expert panel regard inhaled corticosteroids as acceptable to use while breastfeeding. Taken by mouth, budesonide has an oral bioavailability of only about 9%, so any budesonide that reaches the breastmilk is likely to be absorbed by the infant at a similarly low level.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.