Brimonidine Tartrate + Timolol Maleate
Indications
Timo-Plus eye drops help lower high pressure inside the eye (intraocular pressure, or IOP) in people with glaucoma or ocular hypertension.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Brimonidine Tartrate/Timolol Maleate eye drops combine two active ingredients that work together to lower eye pressure. Brimonidine Tartrate is a selective alpha-2 adrenergic receptor agonist with a dual mode of action: it reduces the production of aqueous humor (the fluid inside the eye) and also increases uveoscleral outflow, the drainage pathway that is not dependent on pressure. Timolol Maleate is a beta-adrenergic receptor antagonist that lowers intraocular pressure (IOP) by reducing aqueous humor production; it lacks significant intrinsic sympathomimetic, direct myocardial depressant, or local anesthetic (membrane-stabilizing) activity. Because the two drugs act through complementary mechanisms, the combination takes effect quickly, with the greatest reduction in eye pressure typically seen within two hours of use.
Pregnancy & Breastfeeding
Pregnancy & Breastfeeding: There haven't been enough well-controlled studies looking at this combination's safety in pregnant women. It should only be used during pregnancy if the potential benefit to the mother outweighs any possible risk to the unborn baby. Timolol does pass into breast milk, though it isn't yet known whether Brimonidine Tartrate does too. Given this, a decision should be made about whether to stop breastfeeding or stop the medicine, weighing how important the treatment is for the mother.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.