Betamethasone + Calcipotriol

Indications

Psoriasis

Soria-D topical ointment is used to treat plaque-type psoriasis vulgaris on areas of the skin suitable for topical therapy. Soria-D topical suspension is used to treat plaque psoriasis affecting the scalp and body.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Betamethasone Dipropionate is a potent, topically active corticosteroid that produces a prompt, marked and prolonged anti-inflammatory, antipruritic, vasoconstrictive and immunosuppressive effect, without curing the underlying condition. These effects can be enhanced under occlusive conditions, since occlusion increases penetration through the stratum corneum by roughly 10 times. Calcipotriol is a non-steroidal antipsoriatic agent derived from vitamin D. It exhibits a vitamin D-like effect by competing for the 1,25(OH)2D3 receptor. In regulating cell proliferation and differentiation, Calcipotriol is about as potent as 1,25(OH)2D3, the naturally occurring active form of vitamin D, but it is far less active than 1,25(OH)2D3 in its effect on calcium metabolism. Calcipotriol induces differentiation and suppresses proliferation of keratinocytes, with no evidence of a cytotoxic effect, thereby reversing the abnormal keratinocyte changes seen in psoriasis. The therapeutic goal of Calcipotriol treatment is thus to normalize epidermal growth.

Pregnancy & Breastfeeding

There are no adequate, well-controlled studies looking at the use of this ointment or suspension in pregnant women. It should be used during pregnancy only if the expected benefit to the mother clearly outweighs any possible risk to the unborn baby. Corticosteroids taken systemically are known to pass into human breast milk, and in a nursing infant this can potentially slow growth, interfere with the baby's own natural corticosteroid production, or lead to other unwanted effects. It is not clear whether calcipotriol or betamethasone applied to the skin is absorbed into the body in amounts large enough to show up in breast milk. Since many medicines do pass into breast milk, this ointment or suspension should be used with caution in a breastfeeding mother.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Topical Ointment: This ointment is meant for topical use only. Its phototoxic effects have not been studied in people with psoriasis. Wherever possible, psoriasis-affected areas treated with this ointment should be protected from direct sunlight and UV light using clothing. Adults: apply the ointment to the affected area once daily. The daily dose should not exceed 15 gm, and the weekly dose should not exceed 100 gm. The treated area should cover no more than 30% of the body surface. Use should be intermittent, for up to one year, under close medical supervision. Treatment periods should be limited to four weeks, with Calcipotriol used alone for one month between periods of use of this ointment as needed. Children: this ointment is not recommended for children or adolescents under 18 years of age. Topical Suspension: spray the required amount onto the affected areas once daily and gently rub in with the fingertips. Treatment may continue for up to 8 weeks and may be stopped earlier if symptoms clear. The weekly dose should not exceed 100 gm. Shake before use. This topical suspension is not meant for oral, ophthalmic, or intravaginal use.