Indications
Azonam is indicated for the treatment of the following infections caused by susceptible Gram-negative microorganisms. It is used for urinary tract infections, complicated and uncomplicated, including pyelonephritis and cystitis, whether initial or recurrent, caused by Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Enterobacter cloacae, Klebsiella oxytoca, Citrobacter species and Serratia marcescens. It is also used for lower respiratory tract infections, including pneumonia and bronchitis, caused by Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Haemophilus influenzae, Proteus mirabilis, Enterobacter species and Serratia marcescens. It is used for septicemia caused by Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis, Serratia marcescens and Enterobacter species, as well as for skin and skin-structure infections, including those associated with postoperative wounds, ulcers and burns, caused by Escherichia coli, Proteus mirabilis, Serratia marcescens, Enterobacter species, Pseudomonas aeruginosa, Klebsiella pneumoniae and Citrobacter species. It is further indicated for intra-abdominal infections, including peritonitis, caused by Escherichia coli, Klebsiella species including K. pneumoniae, Enterobacter species including E. cloacae, Pseudomonas aeruginosa, Citrobacter species including C. freundii and Serratia species including S. marcescens, and for gynecologic infections, including endometritis and pelvic cellulitis, caused by Escherichia coli, Klebsiella pneumoniae, Enterobacter species including E. cloacae and Proteus mirabilis. It may also be used as adjunctive therapy to surgery in the management of infections caused by susceptible organisms.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Aztreonam is a synthetic monobactam antibiotic that kills bacteria by stopping the synthesis of their cell walls. It works by binding strongly to penicillin binding protein 3 (PBP3), which blocks the final stage of peptidoglycan crosslinking, the process that holds the bacterial cell wall together. With PBP3 blocked, the bacterium's own cell wall enzymes, known as autolysins, go on to break down the wall and cause the cell to rupture. Aztreonam may also work by interfering with a natural inhibitor of these autolysins.
Pregnancy & Breastfeeding
Pregnancy Category B. Aztreonam crosses the placenta and reaches the fetal circulation, so it should be used during pregnancy only if the potential benefit justifies the potential risk. It is excreted in breast milk at concentrations that are less than 1% of those found in the mother's serum at the same time. Nursing mothers are advised to temporarily stop breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.