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Amiodarone Hydrochloride

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Indications

Cardiac Arrhythmia

Cardiron tablet is used to treat many serious heart rhythm disorders, including ventricular fibrillation, ventricular tachycardia, atrial fibrillation, and atrial flutter. Cardiron injection is an antiarrhythmic medicine used to begin treatment for, and to help prevent, frequently recurring episodes of ventricular fibrillation (VF) and hemodynamically unstable ventricular tachycardia (VT) in patients who have not responded to other treatments.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Amiodarone Hydrochloride is used to correct abnormal heart rhythms. It is considered a "broad-spectrum" antiarrhythmic medicine, meaning it works through several electrical effects on the heart rather than just one. Its most important actions include: delaying the rate at which the heart's electrical system "recharges" after each heartbeat (repolarisation); prolonging the phase in which the heart's muscle cells are electrically stimulated (the action potential); slowing the speed at which electrical impulses travel through the heart's conduction system; reducing the rate at which the heart's natural pacemaker fires impulses; and slowing conduction through extra, specialised electrical pathways (accessory pathways) that may exist in the heart.

Besides its antiarrhythmic action, Amiodarone also relaxes and widens blood vessels. This can make it useful for people with congestive heart failure, though it may also cause blood pressure to drop.

Pregnancy & Breastfeeding

Pregnancy and Breastfeeding: As a general rule, Amiodarone should be avoided during pregnancy, since oral use of the drug in pregnant women has been linked to reports of hypothyroidism or hyperthyroidism in the newborn. If, despite this, a doctor considers Amiodarone essential, the patient should be made aware of the potential risk to the unborn baby. Whether Amiodarone can be used safely by breastfeeding mothers has not yet been established.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Tablet: The usual dose is 200 mg 3 times daily for 1 week, then reduced to 200 mg twice daily, or the minimum dose needed to control the arrhythmia. Amiodarone is usually given in several doses through the day to minimize the stomach upset that is seen more often with higher doses. For this same reason, it is also recommended that Amiodarone be taken with meals. Injection: The recommended starting dose is about 1000 mg over the first 24 hours of therapy, given by the following infusion regimen. First, an initial load of 150 mg per 100 mL (in D5W or Normal Saline) is infused over 10 minutes. This is followed by an infusion of 1 mg per minute for 6 hours, followed by 0.5 mg per minute after that. If breakthrough episodes of VF or hemodynamically unstable VT occur, the initial load described above should be repeated as needed, infused over 10 minutes, and the rate of the maintenance infusion increased to achieve effective suppression of the arrhythmia.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.