Community data Updated 2 months ago

Aminocaproic Acid

Anti-fibrinolytic drugs Prescription

Indications

Caprolex is used to treat excessive bleeding after surgery, especially in procedures where significant blood loss is expected, such as cardiac surgery. It can be given by mouth or by injection into a vein. A meta-analysis found that lysine analogs like Caprolex significantly reduced blood loss in patients undergoing coronary artery bypass grafting. Caprolex can also be used to treat overdose or toxic effects from the thrombolytic medicines tissue plasminogen activator and streptokinase.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

The fibrinolysis-inhibiting effect of aminocaproic acid comes mainly from its ability to block plasminogen activators, with a smaller contribution from direct antiplasmin activity.

Pregnancy & Breastfeeding

Pregnancy Category C. No animal reproduction studies have been carried out with aminocaproic acid, and it is not known whether the drug can harm the fetus when given to a pregnant woman, or whether it can affect fertility. For this reason, Aminocaproic Acid Injection should be used during pregnancy only if there is a clear need for it.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Dosage of Aminocaproic acid must be adjusted to the individual case according to the severity of the bleeding episode. It should be kept in mind that Aminocaproic acid is cleared rapidly through the kidneys, so administration must be repeated every 4 to 6 hours. The average dose is 8 to 16 grams a day, that is, 1 ampule of Aminocaproic acid depending on the case, every 6 hours. Aminocaproic acid is equally effective when taken by mouth or given by intravenous injection. In particularly severe cases, or when a high blood concentration needs to be reached quickly, it is advisable to begin treatment intravenously, with a slow injection of two Aminocaproic acid ampules 30 to 60 minutes apart, then continuing with divided doses until a total of 20 to 25 grams is reached over 24 hours. In all cases, the drug should be continued until all symptoms have completely resolved. Aminocaproic acid may be given intravenously after suitable dilution in physiological saline solution.