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Ambroxol Hydrochloride

Cough expectorants & mucolytics Prescription
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Indications

Asthma Chronic Obstructive Pulmonary Disease Allergic Rhinitis Cough Pneumonia Bronchitis Sinusitis Pharyngitis

Kofmelt is indicated for productive cough and for acute and chronic inflammatory disorders of the upper and lower respiratory tract associated with viscid mucus, including acute and chronic bronchitis. It is also used for inflammatory disease of the rhinopharyngeal tract, such as laryngitis, pharyngitis, sinusitis and rhinitis, when associated with viscid mucus, as well as for asthmatic bronchitis and bronchial asthma with thick expectoration, bronchiectasis, chronic pneumonia and similar conditions.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Ambroxol is the active metabolite of bromhexine, and studies have shown it to have a stronger bronchosecretolytic effect than its parent compound. It improves sputum rheology through a hydrating action that thins mucus within the respiratory tract, making it easier to cough up and easing breathlessness. The drug stimulates alveolar cells to produce surfactant phospholipids, helping to lower surface tension within the alveoli, and it reduces bronchial hyperreactivity. Ambroxol also carries anti-inflammatory properties, working by suppressing the release of cellular cytokines and arachidonic acid metabolites. In patients with COPD, it has traditionally been used to improve airway patency.

Pregnancy & Breastfeeding

Studies looking at birth-defect and fetal-toxicity risk have not shown Ambroxol Hydrochloride to be harmful. Even so, it is advised not to be used during pregnancy, especially in the 1st trimester. Its safety during breastfeeding has not yet been established.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Average daily dose, preferably after meals: For Pediatric Drops, ages 0 to 6 months take 0.5 ml twice a day, ages 6 to 12 months take 1 ml twice a day, and ages 1 to 2 years take 1.25 ml twice a day. For Syrup, ages 2 to 5 years take 2.5 ml (half a teaspoonful) 2 to 3 times a day, ages 5 to 10 years take 5 ml (one teaspoonful) 2 to 3 times a day, and ages 10 years and above, including adults, take 10 ml (two teaspoonfuls) 3 times a day. For the Sustained Release Capsule, adults and children over 12 years old take 1 capsule once daily.