Indications
Virodip is used to treat chronic hepatitis B in adults who have active viral replication, along with either persistently raised liver enzymes (ALT or AST) or evidence of active liver disease on biopsy.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Adefovir dipivoxil is a diester prodrug of adefovir, an acyclic nucleotide analog that acts against the hepatitis B virus (HBV). Once inside the body, cellular kinases convert adefovir into its active form, adefovir diphosphate. This active metabolite blocks HBV DNA polymerase (reverse transcriptase) by competing with the natural substrate deoxyadenosine triphosphate, and once incorporated into the viral DNA strand, it halts further chain formation.
Following a single 10 mg oral dose, adefovir shows an approximate bioavailability of 59%. It binds only minimally to human plasma or serum proteins, at about 4% in vitro. The drug is cleared from the body through the kidneys, via a combination of glomerular filtration and active tubular secretion.
Pregnancy & Breastfeeding
Pregnancy Category C. No adequate, well-controlled studies have looked at adefovir dipivoxil use in pregnant women. It should be used during pregnancy only if clearly needed, after weighing the potential risks against the benefits. Whether adefovir passes into human breast milk isn't known, so mothers taking adefovir dipivoxil should be advised not to breast-feed.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.